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Substance Name: Ribociclib succinate [USAN]
RN: 1374639-75-4
UNII: BG7HLX2919
InChIKey: NHANOMFABJQAAH-UHFFFAOYSA-N

Note

  • Inhibits both CDK4 and CDK6

    NCI: An orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. (NCI Thesaurus)

Molecular Formula

  • C23-H30-N8-O.C4-H6-O4

Molecular Weight

  • 552.6324
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Ribociclib succinate
  • Ribociclib succinate [USAN]

Synonyms

  • Butanedioic acid, compd. with 7-cyclopentyl-N,N-dimethyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-7H-pyrrolo(2,3-d)pyrimidine-6-carboxamide (1:1)
  • Kisqali
  • LEE-011 succinate
  • LEE011-BBA
  • Ribociclib succinate
  • UNII-BG7HLX2919

Registry Numbers

CAS Registry Number

  • 1374639-75-4

FDA UNII

  • BG7HLX2919

System Generated Number

  • 1374639754

Structure Descriptors

InChI

1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8)

InChIKey

NHANOMFABJQAAH-UHFFFAOYSA-N

Smiles

CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N4CCNCC4)nc2n1C5CCCC5.OC(=O)CCC(=O)O