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Substance Name: Dioxopromethazine
RN: 13754-56-8
UNII: 6OOT1MR6XS
InChIKey: FDXKCOBAFGSMDJ-UHFFFAOYSA-N

Molecular Formula

  • C17-H20-N2-O2-S.Cl-H

Molecular Weight

  • 316.423
 
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Names and Synonyms

Name of Substance

  • Dioxopromethazine

Synonyms

  • 5,5-Dioxo-10-(2-(dimethylamino)propyl)phenothiazine hydrochloride
  • 9,9-Dioxo-10-(2-dimethylaminopropyl)-phenothiazinhydrochlorid
  • 9,9-Dioxo-10-(2-dimethylaminopropyl)-phenothiazinhydrochlorid [German]
  • 9,9-Dioxopromethazine
  • 9,9-Dioxypromethazin
  • Dioxopromethazin
  • Dioxopromethazine hydrochloride
  • Dioxoprothazin
  • Promethazine 5,5-dioxide
  • Promethazine SS oxide
  • Prothanon
  • UNII-6OOT1MR6XS

Systematic Names

  • 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, 5,5-dioxide (9CI)
  • 10H-Phenothiazine-10-ethanamine,N,N,alpha-trimethyl-,5,5-dioxide
  • Phenothiazine, 10-(2-(dimethylamino)propyl)-, 5,5-dioxide, monohydrochloride
  • Phenothizine, 10-(2-(dimethylamino)propyl)-, 5,5-dioxide (8CI)

Registry Numbers

CAS Registry Number

  • 13754-56-8

FDA UNII

  • 6OOT1MR6XS

System Generated Number

  • 0013754568

Molecular Formulas

Molecular Formula

  • C17-H20-N2-O2-S.Cl-H

Molecular Formula Fragments

  • C17-H20-N2-O2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H20N2O2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)22(20,21)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

InChIKey

FDXKCOBAFGSMDJ-UHFFFAOYSA-N

Smiles

CC(CN1c2ccccc2S(=O)(=O)c3c1cccc3)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 8mg/kg (8mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
guinea pig LD50 oral 225mg/kg (225mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
guinea pig LD50 subcutaneous 33mg/kg (33mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
mouse LD50 intraperitoneal 49mg/kg (49mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
mouse LD50 intravenous 16mg/kg (16mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 155, 1983.
mouse LD50 oral 50mg/kg (50mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 155, 1983.
mouse LD50 subcutaneous 96mg/kg (96mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.
rabbit LD50 oral 165mg/kg (165mg/kg)   Pharmazie. Vol. 25, Pg. 91, 1970.