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Substance Name: Sodium nitroprusside [USP]
RN: 13755-38-9
UNII: EAO03PE1TC
InChIKey: WSBBPAPVICMLSC-UHFFFAOYSA-N

Note

  • A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.

Molecular Formulas

  • C5-Fe-N6-Na2-O
  • C5-Fe-N6-O.2H2-O.2Na
  • C5-Fe-N6-O.2Na.2H2-O

Molecular Weight

  • 303.998
 

Classification Code

  • Antihypertensive

Names and Synonyms

Name of Substance

  • Sodium nitroprusside dihydrate
  • Sodium nitroprusside [USP]

Synonyms

  • AI3-28742
  • Disodium nitroprusside dihydrate
  • Disodium pentacyanonitrosylferrate(2-) dihydrate
  • Nipride
  • Nitropress
  • Nitroprusid-natrium
  • Nitropruss
  • Nitroprussiate de sodium
  • Nitroprussiate de sodium [French]
  • Sodium nitroferricyanide dihydrate
  • Sodium nitroprussiate dihydrate
  • Sodium nitroprusside
  • Sodium nitroprusside dihydrate
  • Sodium nitrosylpentacyanoferrate(III) dihydrate
  • UNII-EAO03PE1TC

Systematic Names

  • Ferrate(2-), pentacyanonitrosyl-, disodium, dihydrate
  • Ferrate(2-), pentakis(cyano-C)nitrosyl-, disodium, dihydrate, (OC-6-22)-

Registry Numbers

CAS Registry Number

  • 13755-38-9

FDA UNII

  • EAO03PE1TC

Related Registry Number

  • 15078-28-1 (Parent)

System Generated Number

  • 0013755389

Molecular Formulas

Molecular Formulas

  • C5-Fe-N6-Na2-O
  • C5-Fe-N6-O.2H2-O.2Na
  • C5-Fe-N6-O.2Na.2H2-O

Molecular Formula Fragments

  • C5-Fe-N6-O
  • COMPONENT
  • H2-O
  • Na

Structure Descriptors

InChI

1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q5*-1;-2;3*+1;;

InChIKey

WSBBPAPVICMLSC-UHFFFAOYSA-N

Smiles

[CH-](#N)[Fe-2]([CH-]#N)([CH-]#N)([CH-]#N)([CH-]#N)N#[O+].O.O.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1mg/kg (1mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
cat LDLo subcutaneous 50mg/kg (50mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: NAUSEA OR VOMITING
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
child TDLo intravenous 11700ug/kg/60 (11.7mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Clinical Pediatrics Vol. 31, Pg. 380, 1992.
dog LDLo intravenous 1mg/kg (1mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
dog LDLo subcutaneous 80mg/kg (80mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
frog LDLo subcutaneous 40mg/kg (40mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
mouse LD50 intraperitoneal 9mg/kg (9mg/kg)   Annales de l'Anesthesiologie Francaise. Vol. 18(2), Pg. 153, 1977.
mouse LD50 intravenous 6mg/kg (6mg/kg)   Annales de l'Anesthesiologie Francaise. Vol. 18(2), Pg. 153, 1977.
mouse LDLo subcutaneous 9500ug/kg (9.5mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
pigeon LDLo subcutaneous 10mg/kg (10mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
rabbit LD50 intravenous 1800ug/kg (1.8mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1092, 1979.
rabbit LDLo oral 40mg/kg (40mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
rabbit LDLo subcutaneous 4800ug/kg (4.8mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
rat LD50 intraperitoneal 7mg/kg (7mg/kg)   Annales de l'Anesthesiologie Francaise. Vol. 18(2), Pg. 153, 1977.
rat LD50 intravenous 9300ug/kg (9.3mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 1092, 1979.
rat LDLo oral 20mg/kg (20mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 883, 1980.