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Substance Name: Etorphine hydrochloride
RN: 13764-49-3
UNII: 8CBE01N748
InChIKey: JNHPUZURWFYYHW-DTUSRQQPSA-N

Note

  • A narcotic analgesic morphinan used as a sedative in veterinary practice.

Molecular Formula

  • C25-H33-N-O4.Cl-H

Molecular Weight

  • 447.9996
 

Classification Codes

Classification Code

  • Drug / Therapeutic Agent

Superlist Classification Code

  • DEA Schedule II
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Names and Synonyms

Results Name

  • Etorphine hydrochloride

Name of Substance

  • Etorphine hydrochloride

Synonyms

  • (6R,7R,14R)-7,8-Dihydro-7-((1R)-1-hydroxy-1-methylbutyl)-6-O-methyl-6,14alpha-ethenomorphine hydrochloride
  • 19-Propylorvinol hydrochloride
  • 6,14-Endoetheno-7-(2-hydroxy-2-pentyl)-tetrahydro-oripavine hydrochloride
  • 7-alpha-(1-(R)-Hydroxy-1-methylbutyl)-6,14-endoethenotetrahydro-oripavine hydrochloride
  • EINECS 237-364-7
  • Etorphine HCl
  • Etorphine hydrochloride
  • M 99
  • M 99 reckitt
  • M-99
  • Propylorvinol hydrochloride
  • UNII-8CBE01N748

Systematic Names

  • (5alpha,7alpha(R))-4,5-Epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-6,14-ethenomorphinan-7-methanol hydrochloride
  • 6,14-endo-Ethenotetrahydrooripavine, 7-alpha-(1-(R)-hydroxy-1-methylbutyl)-, hydrochloride

Superlist Names

  • DEA No. 9059
  • Etorphine hydrochloride

Registry Numbers

CAS Registry Number

  • 13764-49-3

FDA UNII

  • 8CBE01N748

System Generated Number

  • 0013764493

Molecular Formulas

Molecular Formula

  • C25-H33-N-O4.Cl-H

Molecular Formula Fragments

  • C25-H33-N-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C25H33NO4.ClH/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24;/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3;1H/t17-,18-,21-,22-,23-,24+,25-;/m1./s1

InChIKey

JNHPUZURWFYYHW-DTUSRQQPSA-N

Smiles

Cl.CCC[C@@](C)(O)[C@H]1C[C@]23C=C[C@]1(OC)[C@@H]4Oc5c(O)ccc6C[C@H]2N(C)CC[C@@]34c56

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 1mg/kg (1mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 26, Pg. 241, 1991.
monkey LD50 intravenous 10ug/kg (0.01mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 26, Pg. 241, 1991.
mouse LD50 intraperitoneal 61mg/kg (61mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 26, Pg. 241, 1991.
mouse LD50 intravenous 80mg/kg (80mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.
mouse LD50 oral 1856mg/kg (1856mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.
mouse LD50 subcutaneous 425mg/kg (425mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.
rabbit LD50 intravenous 8ug/kg (0.008mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 26, Pg. 241, 1991.
rat LD50 intravenous 5300ug/kg (5.3mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.
rat LD50 oral 72mg/kg (72mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.
rat LD50 subcutaneous 53mg/kg (53mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967.