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Substance Name: Mozavaptan [INN]
RN: 137975-06-5
UNII: 17OJ42922Y
InChIKey: WRNXUQJJCIZICJ-UHFFFAOYSA-N

Note

  • Aquaretic agent; vasopressin V2 receptor antagonist.

Classification Codes

  • Antidiuretic Hormone Receptor Antagonists
  • Natriuretic Agents

Molecular Formula

  • C27-H29-N3-O2

Molecular Weight

  • 427.5451
 
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Names and Synonyms

Name of Substance

  • Mozavaptan
  • Mozavaptan [INN]

Synonyms

  • 5-Dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
  • Mozavaptan
  • N-(4-(((5RS)-5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methylbenzamide
  • N-(4-((5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methylbenzamide
  • OPC 31260
  • OPC-31260
  • UNII-17OJ42922Y

Systematic Name

  • Benzamide, N-(4-((5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methyl-

Registry Numbers

CAS Registry Number

  • 137975-06-5

FDA UNII

  • 17OJ42922Y

System Generated Number

  • 0137975065

Structure Descriptors

InChI

1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)

InChIKey

WRNXUQJJCIZICJ-UHFFFAOYSA-N

Smiles

CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c4ccccc14

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo oral 1500mg/kg (1500mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Biological and Pharmaceutical Bulletin. Vol. 23, Pg. 182, 2000.