Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Deferoxamine mesylate [USAN:USP]
RN: 138-14-7
UNII: V9TKO7EO6K
InChIKey: IDDIJAWJANBQLJ-UHFFFAOYSA-N

Note

  • Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.

Molecular Formula

  • C25-H48-N6-O8.C-H4-O3-S

Molecular Weight

  • 656.794
 

Classification Codes

  • Antidote (to Iron Poisoning)
  • Chelating Agent
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Deferoxamine mesylate [USAN:USP]

MeSH Heading

  • Deferoxamine

Synonyms

  • Ba 33122
  • Ba-33112
  • Butanediamide, N'-(5-((4-((5-(acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate
  • CCRIS 8311
  • Deferoxamine B mesylate
  • Deferoxamine mesilate
  • Deferoxamine mesylate
  • Deferoxamine methanesulfonate
  • Desferal
  • Desferal mesylate
  • Desferal methanesulfonate
  • Desferrioxamine B mesylate
  • Desferrioxamine B methanesulfonate
  • Desferrioxamine mesilate
  • Desferrioxamine mesylate
  • Desferrioxamine methanesulfonate
  • EINECS 205-314-3
  • N-(5-(3-((5-Aminopentyl)hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N-hydroxyacetamido)pentyl)carbamoyl)propionohydroxamic acid monomethanesulfonate (salt)
  • UNII-V9TKO7EO6K

Systematic Names

  • Butanediamide, N'-(5-((4-((5-(acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate
  • Deferoxamine mesilate
  • Propionohydroxamic acid, N-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N-hydroxyacetamido)pentyl)carbamoyl)-, monomethanesulfonate (salt)

Registry Numbers

CAS Registry Number

  • 138-14-7

FDA UNII

  • V9TKO7EO6K

Other Registry Numbers

  • 17688-38-9
  • 35908-62-4

System Generated Number

  • 0000138147

Molecular Formulas

Molecular Formula

  • C25-H48-N6-O8.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C25-H48-N6-O8
  • COMPONENT

Structure Descriptors

InChI

1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)

InChIKey

IDDIJAWJANBQLJ-UHFFFAOYSA-N

Smiles

C(CCC(=O)NCCCCCN(C(C)=O)O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O.CS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo parenteral 16gm/kg/34W-I (16000mg/kg) CARDIAC: PERICARDITIS

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

BLOOD: OTHER CHANGES
American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.
man TDLo subcutaneous 143mg/kg/4D-I (143mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
British Medical Journal. Vol. 291, Pg. 448, 1985.
mouse LD50 intraperitoneal 1240mg/kg (1240mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973.
mouse LD50 intravenous 273mg/kg (273mg/kg)   Drugs in Japan Vol. 6, Pg. 496, 1982.
mouse LD50 oral 15200mg/kg (15200mg/kg)   Drugs in Japan Vol. 6, Pg. 496, 1982.
mouse LD50 subcutaneous 1280mg/kg (1280mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973.
rat LD50 intravenous 330mg/kg (330mg/kg)   Drugs in Japan Vol. 6, Pg. 496, 1982.
rat LD50 oral 17300mg/kg (17300mg/kg)   Drugs in Japan Vol. 6, Pg. 496, 1982.
rat LD50 subcutaneous 5500mg/kg (5500mg/kg)   Drugs in Japan Vol. 6, Pg. 496, 1982.
women TDLo subcutaneous 150mg/kg/4D-I (150mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
British Medical Journal. Vol. 291, Pg. 448, 1985.
women TDLo unreported 900mg/kg/30W- (900mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
American Journal of Medicine. Vol. 87, Pg. 468, 1989.