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Substance Name: Mafenide hydrochloride
RN: 138-37-4
UNII: 3J751V0284
InChIKey: SIACJRVYIPXFKS-UHFFFAOYSA-N

Note

  • /Mafenide acetate/ A sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.

Molecular Formula

  • C7-H10-N2-O2-S.Cl-H

Molecular Weight

  • 222.6949
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
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Names and Synonyms

Name of Substance

  • Mafenide hydrochloride

Synonyms

  • 4-Aminomethylbenzenesulfonamide hydrochloride
  • 4-Homosulfanilamide hydrochloride
  • AI3-16157
  • alpha-Amino-p-toluenesulfonamide hydrochloride
  • Ambamide hydrochloride
  • EINECS 205-325-3
  • Emilene hydrochloride
  • Homosulfamine
  • Homosulfamine hydrochloride
  • Homosulfanilamide hydrochloride
  • Mafenide HCl
  • Mafenide hydrochloride
  • Maphenide hydrochloride
  • Marfanil
  • Masudin
  • Mesudin hydrochloride
  • Mesudrin hydrochloride
  • Morfanil
  • Neofamid hydrochloride
  • NSC 3527
  • p-(Aminomethyl)benzenesulfonamide hydrochloride
  • p-(Aminomethyl)benzenesulfonamide monohydrochloride
  • p-Aminomethylphenylsulfonamide hydrochloride
  • p-Toluenesulfonamide, alpha-amino-, hydrochloride
  • Sulfamylon hydrochloride
  • Sulfbenzamine hydrochloride
  • UNII-3J751V0284

Systematic Names

  • Benzenesulfonamide, 4-(aminomethyl)-, monohydrochloride (9CI)
  • Mafenide hydrochloride
  • p-Toluenesulfonamide, alpha-amino-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 138-37-4

FDA UNII

  • 3J751V0284

System Generated Number

  • 0000138374

Molecular Formulas

Molecular Formula

  • C7-H10-N2-O2-S.Cl-H

Molecular Formula Fragments

  • C7-H10-N2-O2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C7H10N2O2S.ClH/c8-5-6-1-3-7(4-2-6)12(9,10)11;/h1-4H,5,8H2,(H2,9,10,11);1H

InChIKey

SIACJRVYIPXFKS-UHFFFAOYSA-N

Smiles

c1cc(ccc1CN)S(=O)(=O)N.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 900mg/kg (900mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Life Sciences. Vol. 5, Pg. 2279, 1966.
mouse LD50 oral 8gm/kg (8000mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 49, Pg. 11, 1953.
mouse LD50 subcutaneous 3500mg/kg (3500mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 49, Pg. 11, 1953.
mouse LDLo intramuscular 3500mg/kg (3500mg/kg)   Lancet. Vol. 2, Pg. 523, 1944.
mouse LDLo intraperitoneal 2500mg/kg (2500mg/kg)   Lancet. Vol. 2, Pg. 523, 1944.
rat LD50 intravenous 1170mg/kg (1170mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Life Sciences. Vol. 5, Pg. 2279, 1966.