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Substance Name: Betazole hydrochloride [USP:JAN]
RN: 138-92-1
UNII: 66ABP6C83F
InChIKey: BUXCUOWXTOKEMQ-UHFFFAOYSA-N

Note

  • A histamine H2 agonist used clinically to test gastric secretory function.

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C5-H9-N3.2Cl-H

Molecular Weight

  • 184.0689
 
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Names and Synonyms

Name of Substance

  • Betazole dihydrochloride
  • Betazole hydrochloride [USP:JAN]

Synonyms

  • 1H-Pyrazole-3-ethanamine, dihydrochloride
  • 2-(3-Pyrazolyl)ethylamine dihydrochloride
  • 3,5-beta-Pyrazoleethylamine dihydrochloride
  • 3-(2-Aminoethyl)pyrazole dihydrochloride
  • 3-beta-Aminoethylpyrazole dihydrochloride
  • Ametazole dihydrochloride
  • Betazole dihydrochloride
  • Betazole HCl
  • Betazole hydrochloride
  • EINECS 205-345-2
  • Gastramine
  • Histalog
  • Histimin
  • UNII-66ABP6C83F

Systematic Names

  • 1H-Pyrazole-3-ethanamine, dihydrochloride
  • Betazole dihydrochloride
  • Pyrazole, 3-(2-aminoethyl)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 138-92-1

FDA UNII

  • 66ABP6C83F

Related Registry Number

  • 105-20-4 (Parent)

System Generated Number

  • 0000138921

Molecular Formulas

Molecular Formula

  • C5-H9-N3.2Cl-H

Molecular Formula Fragments

  • C5-H9-N3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C5H9N3.2ClH/c6-3-1-5-2-4-7-8-5;;/h2,4H,1,3,6H2,(H,7,8);2*1H

InChIKey

BUXCUOWXTOKEMQ-UHFFFAOYSA-N

Smiles

Cl.Cl.c1(CCN)cc[nH]n1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo ocular 86ug/kg/6D-I (0.086mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA American Journal of Ophthalmology. Vol. 102, Pg. 274, 1986.
mouse LD50 intravenous 803mg/kg (803mg/kg)   Drugs in Japan Vol. 6, Pg. 749, 1982.
mouse LD50 oral 860mg/kg (860mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 122, Pg. 685, 1966.
women TDLo ocular 740ug/kg/37D- (0.74mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: ANOREXIA (HUMAN
American Journal of Ophthalmology. Vol. 102, Pg. 275, 1986.