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Substance Name: Ukrain
RN: 138069-52-0
UNII: 6251Q9UK1S
InChIKey: KIGCDEJCMKDBHU-NIQQUOCOSA-K

Note

  • A phytogenic antineoplastic agent; semisynthetic product from alkaloids of Chelidonium majus L. & thiophosphoric triaciridide acid.

Molecular Weight

  • 1303.38
 

Classification Codes

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Natural Product
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ukrain

Synonyms

  • CCRIS 6300
  • Ukrain
  • UKSR-222
  • UNII-6251Q9UK1S

Systematic Name

  • Ukrain

Registry Numbers

CAS Registry Number

  • 138069-52-0

FDA UNII

  • 6251Q9UK1S

System Generated Number

  • 0138069520

Structure Descriptors

InChI

1S/C66H72N6O15PS.3H2O/c1-70(25-43-37(4-7-49-64(43)85-31-76-49)58-46(73)16-34-19-52-55(82-28-79-52)22-40(34)61(58)70)13-10-67-88(89,68-11-14-71(2)26-44-38(5-8-50-65(44)86-32-77-50)59-47(74)17-35-20-53-56(83-29-80-53)23-41(35)62(59)71)69-12-15-72(3)27-45-39(6-9-51-66(45)87-33-78-51)60-48(75)18-36-21-54-57(84-30-81-54)24-42(36)63(60)72;;;/h4-9,19-24,46-48,58-63,73-75H,10-18,25-33H2,1-3H3,(H3,67,68,69,89);3*1H2/q+3;;;/p-3/t46-,47-,48-,58-,59-,60-,61+,62+,63+,70?,71?,72?,88?;;;/m0.../s1

InChIKey

KIGCDEJCMKDBHU-NIQQUOCOSA-K

Smiles

[OH-].O1c2c(OC1)c1C[N@@+]([C@H]3[C@@H]([C@H](Cc4cc5OCOc5cc34)O)c1cc2)(C)CCNP(NCC[N@@+]1([C@@H]2c3cc4OCOc4cc3C[C@@H]([C@@H]2c2c(c3OCOc3cc2)C1)O)C)(=S)NCC[N@@+]1([C@@H]2c3cc4OCOc4cc3C[C@@H]([C@@H]2c2c(C1)c1OCOc1cc2)O)C.[OH-].[OH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 190mg/kg (190mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 44, Pg. 227, 1992.
mouse LD50 intraperitoneal 190mg/kg (190mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Polish Journal of Pharmacology and Pharmacy. Vol. 44, Pg. 227, 1992.
mouse LD50 oral 460mg/kg (460mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 44, Pg. 227, 1992.
mouse LD50 oral 460mg/kg (460mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Polish Journal of Pharmacology and Pharmacy. Vol. 44, Pg. 227, 1992.
rat LD50 intraperitoneal 280mg/kg (280mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 44, Pg. 227, 1992.
rat LD50 intraperitoneal 280mg/kg (280mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: TREMOR
Polish Journal of Pharmacology and Pharmacy. Vol. 44, Pg. 227, 1992.
rat LD50 intravenous 318mg/kg (318mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Drugs under Experimental and Clinical Research. Vol. 24, Pg. 287, 1998.
rat LD50 oral > 1gm/kg (1000mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Polish Journal of Pharmacology and Pharmacy. Vol. 44, Pg. 227, 1992.