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Substance Name: Leteprinim [INN]
RN: 138117-50-7
UNII: NBY3IU407M
InChIKey: JMPOIZCOJJMTHI-UHFFFAOYSA-N

Note

  • A neuroprotective agent that has been shown to improve memory; induces NGF-dependent nociceptive nerve sprouting.

Molecular Formula

  • C15-H13-N5-O4

Molecular Weight

  • 327.2987
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Leteprinim [INN]

Name of Substance

  • 4-((3-(1,6-Dihyro-6-oxo-9H-purin-9-yl)-1-oxopropyl)amino)benzoic acid
  • Leteprinim [INN]

Synonyms

  • 4-((3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl)amino)benzoic acid
  • AIT 082
  • AIT 082 acid
  • Leteprinim
  • N-(4-Carboxyphenyl)-3-(6-oxohydropurin-9-yl)propanamide
  • p-(3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)propionamido)benzoic acid
  • UNII-NBY3IU407M

Systematic Name

  • Benzoic acid, 4-((3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl)amino)-

Registry Numbers

CAS Registry Number

  • 138117-50-7

FDA UNII

  • NBY3IU407M

System Generated Number

  • 0138117507

Structure Descriptors

InChI

1S/C15H13N5O4/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22)

InChIKey

JMPOIZCOJJMTHI-UHFFFAOYSA-N

Smiles

c1cc(ccc1C(=O)O)NC(=O)CCn2cnc3c2nc[nH]c3=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #5447939,
mouse LD50 oral > 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #5447939,
rat LD50 intraperitoneal > 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #5447939,
rat LD50 oral > 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #5447939,