Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Enflurane [USAN:USP:INN:BAN:JAN]
RN: 13838-16-9
UNII: 91I69L5AY5
InChIKey: JPGQOUSTVILISH-UHFFFAOYSA-N

Note

  • An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.

Molecular Formula

  • C3-H2-Cl-F5-O

Molecular Weight

  • 184.4908
 

Classification Codes

Classification Codes

  • Anesthetic (Inhalation)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Inhalation
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Code

  • TWA (75 ppm); Not classifiable as a human carcinogen

Names and Synonyms

Name of Substance

  • Enflurane
  • Enflurane [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Enflurane

Synonyms

  • (+-)-2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
  • 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
  • 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
  • Anesthetic 347
  • Anesthetic Compound No. 347
  • BRN 1903921
  • C 347
  • Compound 347
  • Efrane
  • EINECS 237-553-4
  • Enflurane
  • Enflurano
  • Enflurano [INN-Spanish]
  • Enfluranum
  • Enfluranum [INN-Latin]
  • Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-
  • Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-, (+-)-
  • Ethrane
  • HSDB 7909
  • Methylflurether
  • NSC-115944
  • OHIO 347
  • UNII-91I69L5AY5

Systematic Names

  • Enflurane
  • Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-
  • Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl

Superlist Names

  • Enflurane
  • Enflurane [Anaesthetics, volatile]

Registry Numbers

CAS Registry Number

  • 13838-16-9

FDA UNII

  • 91I69L5AY5

System Generated Number

  • 0013838169

Structure Descriptors

InChI

1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H

InChIKey

JPGQOUSTVILISH-UHFFFAOYSA-N

Smiles

C(C(OC(F)F)(F)F)(F)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TCLo inhalation 1pph/6H (10000ppm) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Anesthesiology. Vol. 45, Pg. 557, 1976.
mouse LC50 inhalation 8100ppm/3H (8100ppm)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
mouse LD50 intraperitoneal 3900uL/kg (3.9mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981.
mouse LD50 oral 5mL/kg (5mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981.
mouse LD50 subcutaneous 38800uL/kg (38.8mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981.
rat LC50 inhalation 14000ppm/3H (14000ppm)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
rat LD50 intraperitoneal 6mL/kg (6mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981.
rat LD50 oral 5450uL/kg (5.45mL/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981.
rat LD50 subcutaneous 19500uL/kg (19.5mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Boiling Point 56.5 deg C   EXP
log P (octanol-water) 2.1 (none)   EXP
Water Solubility 5620 mg/L 37 EXP
Vapor Pressure 591 mm Hg 25 EST
Henry's Law Constant 0.013 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.19E-14 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.