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Substance Name: Colforsin daropate hydrochloride
RN: 138605-00-2
UNII: C6P4R272GT
InChIKey: VIRRLEDAYYYTOD-YHEOSNBFSA-N

Note

  • Acts as direct activator of adenyl cyclase; improves drug-induced cardiac failure.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C27-H43-N-O8.Cl-H

Molecular Weight

  • 546.0966
 
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Names and Synonyms

Results Name

  • Colforsin daropate hydrochloride

Name of Substance

  • Colforsin daropate hydrochloride

Synonyms

  • 6-(3-Dimethylaminopropionyl)forskolin hydrochloride
  • Adehl
  • Colforsin dapropate HCl
  • Colforsin dapropate hydrochloride
  • NKH 477
  • NKH477
  • UNII-C6P4R272GT

Systematic Names

  • beta-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester, hydrochloride
  • beta-Alanine, N,N-dimethyl-, 5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester, hydrochloride, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-

Registry Numbers

CAS Registry Number

  • 138605-00-2

FDA UNII

  • C6P4R272GT

System Generated Number

  • 0138605002

Molecular Formulas

Molecular Formula

  • C27-H43-N-O8.Cl-H

Molecular Formula Fragments

  • C27-H43-N-O8
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1

InChIKey

VIRRLEDAYYYTOD-YHEOSNBFSA-N

Smiles

[C@@]12([C@@]([C@H]([C@H]([C@@H]3[C@@]1([C@H](CCC3(C)C)O)C)OC(=O)CCN(C)C)OC(=O)C)(O[C@](CC2=O)(C=C)C)C)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 1600ug/kg (1.6mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 635, 1995.
rat LD50 intravenous 6100ug/kg (6.1mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 635, 1995.
rat LD50 oral 12900ug/kg (12.9mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 49, Pg. 635, 1995.