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Substance Name: Nebacumab [USAN:INN:BAN]
RN: 138661-01-5
UNII: 908FWN27WK

Notes

  • A human monoclonal IgM antibody that binds specifically to the lipid A domain of endotoxin.
  • Withdrawn from clinical trials for treatment of septicemia after excess mortality; monoclonal antiendotoxin agent; MW about 1000 kDa.

Molecular Formula

  • Unspecified
 

Classification Code

  • Monoclonal Antibody (Anti-Endotoxin)
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Names and Synonyms

Name of Substance

  • Nebacumab
  • Nebacumab [USAN:INN:BAN]

Synonyms

  • Centoxin
  • HA IA
  • HA-1A
  • Immunoglobulin M (human monoclonal HA-1A anti-endotoxin), disulfide with human monoclonal HA-1A kappa-chain, pentameric dimer
  • Immunoglobulin M (human monoclonal HA-1A anti-endotoxin), disulfide with human monoclonal HA-1A kappa-chain, pentameric dimer. Molecular weight is approximately 1,000,000 daltons
  • Nebacumab
  • Septomonab
  • UNII-908FWN27WK

Systematic Names

  • Immunoglobulin M (human monoclonal HA-IA anti-endotoxin), disulfide with human monoclonal HA-IA kappa-chain, pentameric dimer
  • Immunoglobulin M, anti-endotoxin (human monoclonal HA-IA mu-chain), disulfide with human monoclonal HA-IA kappa-chain, pentameric dimer

Registry Numbers

CAS Registry Number

  • 138661-01-5

FDA UNII

  • 908FWN27WK

Other Registry Number

  • 138330-99-1

System Generated Number

  • 0138661015