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Substance Name: Arsphenamine [USP]
RN: 139-93-5
UNII: 8BAJ8WP85I
InChIKey: VLAXZGHHBIJLAD-UHFFFAOYSA-N
Note
- An organoarsenic compound that was commonly used for treating SYPHILIS and other diseases.
Molecular Formula
- C12-H12-As2-N2-O2.2Cl-H
Molecular Weight
- 439.0046
- All
- Classifications
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antitreponemal Agents
- Drug / Therapeutic Agent
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Names and Synonyms
Name of Substance
- Arsphenamine
- Arsphenamine [USP]
MeSH Heading
- Arsphenamine
Synonyms
- 3,3'-Diamino-4,4'-dihydroxyarsenobenzene dihydrochloride
- 4,4'-(1,2-Diarsenediyl)bis(2-aminophenol) dihydrochloride
- 606
- Arsabenzosol
- Arsaminol
- Arsenobenzene, 3,3'-diamino-4,4'-dihydroxy-, dihydrochloride
- Arsenobenzol dihydrochloride
- Arsenphenolamine hydrochloride
- Arsfenamin
- Arsfenamin [Czech]
- Arsphenamine
- Diarsenol
- Ehrlich 606
- EINECS 205-386-6
- Eparsenol
- Kharsivan
- Novarsol
- NSC 3097
- Phenarsenamine
- Phenol, 4,4'-arsenobis(2-amino-
- Salavarsan
- Salvarsan
- Sanluol
- Six hundred six
- Tanvarsan
- UNII-8BAJ8WP85I
- X 109
Systematic Names
- 6,6'-Dihydroxy-3,3'-diarsene-1,2-diyldianilinium dichloride
- Phenol, 4,4'-(1,2-diarsenediyl)bis(2-amino)-, dihydrochloride
- Phenol, 4,4'-(1,2-diarsenediyl)bis(2-amino-, dihydrochloride (9CI)
- Phenol, 4,4'-arsenobis(2-amino-, dihydrochloride
Registry Numbers
CAS Registry Number
- 139-93-5
FDA UNII
- 8BAJ8WP85I
System Generated Number
- 0000139935
Molecular Formulas
Molecular Formula
- C12-H12-As2-N2-O2.2Cl-H
Molecular Formula Fragments
- C12-H12-As2-N2-O2
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C12H12As2N2O2.2ClH/c15-9-5-7(1-3-11(9)17)13-14-8-2-4-12(18)10(16)6-8;;/h1-6,17-18H,15-16H2;2*1HInChIKey
VLAXZGHHBIJLAD-UHFFFAOYSA-NSmiles
Cl.Cl.Nc1cc(ccc1O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intravenous | 36mg/kg (36mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 72, Pg. 241, 1913. | |
guinea pig | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
guinea pig | LDLo | subcutaneous | 75mg/kg (75mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
mouse | LD50 | intravenous | 200mg/kg (200mg/kg) | Therapie. Vol. 2, Pg. 28, 1947. | |
mouse | LDLo | intraperitoneal | 162mg/kg (162mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
mouse | LDLo | oral | 2gm/kg (2000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 76, Pg. 358, 1942. | |
mouse | LDLo | subcutaneous | 125mg/kg (125mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
rabbit | LDLo | intravenous | 112mg/kg (112mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
rat | LD | oral | > 500mg/kg (500mg/kg) | National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 12, 1953. | |
rat | LD50 | intravenous | 37mg/kg (37mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 73, Pg. 12, 1941. |
rat | LDLo | intraperitoneal | 112mg/kg (112mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. | |
rat | LDLo | subcutaneous | 175mg/kg (175mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 190 dec | deg C | EXP | |
log P (octanol-water) | 1.860 | (none) | EST | |
Atmospheric OH Rate Constant | 1.48E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.