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Substance Name: Proto-oncogene protein c-cbl
RN: 139076-33-8


  • An oncoprotein from the Cas NS-1 murine retrovirus that induces pre- B-CELL LYMPHOMA and MYELOID LEUKEMIAS. v-cbl protein is a tyrosine-phosphorylated, truncated form of its cellular homologue, PROTO-ONCOGENE PROTEIN C-CBL.
  • Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. It is a UBIQUITIN-PROTEIN LIGASE and the cellular homologue of ONCOGENE PROTEIN V-CBL.
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Names and Synonyms

Name of Substance

  • Proto-oncogene protein c-cbl

MeSH Headings

  • Oncogene Protein v-cbl
  • Proto-Oncogene Proteins c-cbl


  • c-Cbl protein
  • c-Cbl protooncogene product
  • p120(Cbl)
  • p130(Cas)-related crk-associated protein
  • Protein c-cbl

Systematic Name

  • Protein p 135 (human clone 32/53/42 gene c-cbl reduced)

Registry Numbers

CAS Registry Number

  • 139076-33-8

System Generated Number

  • 0139076338