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Substance Name: Kitasamycin [USAN:INN:BAN:JAN]
RN: 1392-21-8
UNII: G986N7X02W

Note

  • A macrolide antibiotic produced by Streptomyces kitasatoensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

Molecular Formula

  • Unspecified

Molecular Weight

  • 686.81
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent
  • Natural Product
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Links to Resources

Names and Synonyms

Name of Substance

  • Kitasamycin
  • Kitasamycin [USAN:INN:BAN:JAN]

MeSH Heading

  • Kitasamycin

Synonyms

  • Ayermicina
  • C 637
  • Kitasamycin
  • Kitasamycine
  • Kitasamycine [INN-French]
  • Kitasamycinum
  • Kitasamycinum [INN-Latin]
  • Quitasamicina
  • Quitasamicina [INN-Spanish]
  • Selectomycin
  • Stereomycine
  • Syneptine
  • UNII-G986N7X02W

Systematic Name

  • Leucomycin

Registry Numbers

CAS Registry Number

  • 1392-21-8

FDA UNII

  • G986N7X02W

Other Registry Numbers

  • 11006-65-8
  • 12646-12-7
  • 8059-95-8

System Generated Number

  • 0001392218

Structure Descriptors

Smiles

O([C@@H]1[C@H](C[C@H]([C@@H](C=CC=CC[C@H](OC(C[C@H]([C@@H]1OC)O)=O)C)O)C)CC=O)[C@@H]1[C@@H]([C@@H]([C@@H](O[C@@H]2C[C@@]([C@@H](O*)[C@@H](O2)C)(C)O)CO1)N(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1758mg/kg (1758mg/kg)   Drugs in Japan Vol. -, Pg. 354, 1995.
mouse LD50 intravenous 650mg/kg (650mg/kg)   Journal of Antibiotics, Series A. Vol. 6, Pg. 87, 1953.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Acta Therapeutica. Vol. 1, Pg. 115, 1975.
mouse LD50 subcutaneous 850mg/kg (850mg/kg)   "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Suppl Exporters' Assoc., 1968Vol. -, Pg. 84, 1968.
rat LD50 intraperitoneal 3000ku/kg (3000000iu/kg)   Drugs in Japan Vol. -, Pg. 354, 1995.
rat LD50 oral > 8gm/kg (8000mg/kg)   Drugs in Japan Vol. -, Pg. 354, 1995.
rat LD50 subcutaneous > 7500mg/kg (7500mg/kg)   Drugs in Japan Vol. -, Pg. 354, 1995.