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Substance Name: Secretin [USAN:INN:BAN:DCF:JAN]
RN: 1393-25-5
UNII: 88C55N56UU
InChIKey: KKNIUBFRGPFELP-UHFFFAOYSA-N

Note

  • A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)

Molecular Weight

  • 3056.42
 

Classification Codes

  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Stimulates Pancreatic and Gastric Secretions to Aid in the Diagnosis of Pancreatic Exocrine Dysfunction and the Diagnosis of Gastrinoma
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Names and Synonyms

Name of Substance

  • Secretin
  • Secretin [USAN:INN:BAN:DCF:JAN]

MeSH Heading

  • Secretin

Synonyms

  • EINECS 215-733-3
  • L-Histidyl-L-seryl-L-alpha-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-alpha-aspartyl-L-seryl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide
  • L-Histidyl-L-seryl-L-alpha-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-alpha-glutamylglycyl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide
  • Secreflo
  • SecreFlow
  • Secrepan
  • Secretin
  • Secretin (porcine)
  • Secretin (porcine), 15-L-glutamic acid-16-glycine-
  • Secretin-ferring
  • Secretin-Kabi
  • Secretina
  • Secretina [INN-Spanish]
  • Secretine
  • Secretine [INN-French]
  • Secretinum
  • Secretinum [INN-Latin]
  • Secretolin
  • UNII-88C55N56UU
  • Vitrum

Systematic Names

  • Hormone of the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level
  • Secretin

Registry Numbers

CAS Registry Number

  • 1393-25-5

FDA UNII

  • 88C55N56UU

Other Registry Number

  • 9002-77-1

Related Registry Number

  • 67307-60-2 (citrate (salt))

System Generated Number

  • 0001393255

Structure Descriptors

InChI

1S/C130H219N43O42/c1-59(2)43-78(118(206)172-99(65(13)14)126(214)215)151-94(182)53-148-104(192)75(31-34-91(132)180)156-113(201)81(46-62(7)8)163-115(203)82(47-63(9)10)161-107(195)72(28-22-38-145-128(136)137)153-110(198)76(32-35-92(133)181)157-114(202)80(45-61(5)6)159-106(194)71(27-21-37-144-127(134)135)152-102(190)66(15)150-120(208)87(55-174)168-117(205)86(52-98(188)189)165-109(197)73(29-23-39-146-129(138)139)154-112(200)79(44-60(3)4)160-108(196)74(30-24-40-147-130(140)141)155-121(209)89(57-176)169-116(204)83(48-64(11)12)162-111(199)77(33-36-96(184)185)158-122(210)90(58-177)170-125(213)101(68(17)179)173-119(207)84(49-69-25-19-18-20-26-69)166-124(212)100(67(16)178)171-95(183)54-149-105(193)85(51-97(186)187)164-123(211)88(56-175)167-103(191)70(131)50-93-142-41-42-143-93/h18-20,25-26,41-42,59-68,70-90,99-101,174-179H,21-24,27-40,43-58,131H2,1-17H3,(H2,132,180)(H2,133,181)(H,142,143)(H,148,192)(H,149,193)(H,150,208)(H,151,182)(H,152,190)(H,153,198)(H,154,200)(H,155,209)(H,156,201)(H,157,202)(H,158,210)(H,159,194)(H,160,196)(H,161,195)(H,162,199)(H,163,203)(H,164,211)(H,165,197)(H,166,212)(H,167,191)(H,168,205)(H,169,204)(H,170,213)(H,171,183)(H,172,206)(H,173,207)(H,184,185)(H,186,187)(H,188,189)(H,214,215)(H4,134,135,144)(H4,136,137,145)(H4,138,139,146)(H4,140,141,147)

InChIKey

KKNIUBFRGPFELP-UHFFFAOYSA-N

Smiles

C([C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(NCC(N[C@@H](C(N[C@@H](C(C)C)C(O)=O)=O)CC(C)C)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCNC(N)=N)=O)CO)=O)CC(C)C)=O)CCC(O)=O)=O)CO)=O)[C@@H](C)O)=O)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](Cc1[nH]ccn1)N)=O)CO)=O)CC(O)=O)=O)=O)[C@@H](C)O)=O)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.
mouse LD50 intravenous > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.
mouse LD50 oral > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.
mouse LD50 subcutaneous > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.
rabbit LD50 intravenous > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 20, Pg. 447, 1978.
rabbit LD50 subcutaneous > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 20, Pg. 447, 1978.
rat LD50 intramuscular > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.
rat LD50 intravenous > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.
rat LD50 oral > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.
rat LD50 subcutaneous > 5ku/kg (5000iu/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 1231, 1978.