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Substance Name: Abrin
RN: 1393-62-0
UNII: 6YCF89P8OX

Note

  • A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different proteins have so far been isolated: Abrus agglutinin, the component responsible for: hemagglutinating activity, & abrins a-d, the toxic principals each consisting of two peptide chains are held together by disulfide bonds.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Natural Product
  • Noxae
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Abrin

MeSH Heading

  • Abrin

Synonyms

  • Abrin
  • Abrin (Abrus precatorius, seeds)
  • Abrins
  • Abrus precatorius, seeds
  • Agglutinin
  • Crab's Eyes
  • HSDB 7434
  • Indian licorice seed
  • Jumble bead
  • Prayer bead
  • Toxalbumin
  • UNII-6YCF89P8OX

Systematic Names

  • Abrin
  • Abrins

Registry Numbers

CAS Registry Number

  • 1393-62-0

FDA UNII

  • 6YCF89P8OX

System Generated Number

  • 0001393620

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human LDLo oral 7ug/kg (0.007mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 2, 1989.
mouse LD50 intraperitoneal 20ug/kg (0.02mg/kg)   Toxicon. Vol. 9, Pg. 97, 1971.
mouse LD50 intravenous 20ug/kg (0.02mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(1), Pg. 107, 1982.
mouse LD50 unreported 20ug/kg (0.02mg/kg)   Toxicon. Vol. 13, Pg. 127, 1975.
rabbit LDLo oral 21mg/kg (21mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: PERITONITIS
AMA Archives of Industrial Health. Vol. 12, Pg. 468, 1955.
rat LDLo oral 300mg/kg (300mg/kg) GASTROINTESTINAL: PERITONITIS

BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
AMA Archives of Industrial Health. Vol. 12, Pg. 468, 1955.