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Substance Name: Oxethazaine hydrochloride
RN: 13930-31-9
UNII: 4SPY42YMPY
InChIKey: AFFQPCNKJKMLTE-UHFFFAOYSA-N

Molecular Formula

  • C28-H41-N3-O3.Cl-H

Molecular Weight

  • 504.111
 
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Names and Synonyms

Name of Substance

  • Oxethazaine hydrochloride

Synonyms

  • 2,2'-((2-Hydroxyethyl)imino)bis(N-(alpha,alpha-dimethylphenethyl)-N-methylacetamide) HCl
  • EINECS 237-698-3
  • Emoren
  • N-Methyl-N-phenyl-tert-butylacetamido-beta-hydroxyethylamine hydrochloride
  • Oxetacaine hydrochloride
  • Oxethazaine HCl
  • Oxethazaine hydrochloride
  • UNII-4SPY42YMPY

Systematic Names

  • Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(alpha,alpha-dimethylphenethyl)-N-methyl-, hydrochloride
  • Oxetacaine hydrochloride

Registry Numbers

CAS Registry Number

  • 13930-31-9

FDA UNII

  • 4SPY42YMPY

Other Registry Number

  • 69343-46-0

Related Registry Number

  • 126-27-2 (Parent)

System Generated Number

  • 0013930319

Molecular Formulas

Molecular Formula

  • C28-H41-N3-O3.Cl-H

Molecular Formula Fragments

  • C28-H41-N3-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C28H41N3O3.ClH/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24;/h7-16,32H,17-22H2,1-6H3;1H

InChIKey

AFFQPCNKJKMLTE-UHFFFAOYSA-N

Smiles

c1c(cccc1)CC(N(C(CN(CC(N(C(Cc1ccccc1)(C)C)C)=O)CCO)=O)C)(C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 266mg/kg (266mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
mouse LD50 intraperitoneal 32670ug/kg (32.67mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Proceedings of the Society for Experimental Biology and Medicine. Vol. 109, Pg. 664, 1962.
mouse LD50 intravenous 3881ug/kg (3.881mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
mouse LD50 oral 431mg/kg (431mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Proceedings of the Society for Experimental Biology and Medicine. Vol. 109, Pg. 664, 1962.
mouse LD50 subcutaneous 89mg/kg (89mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rabbit LD50 intratracheal 453ug/kg (0.453mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rabbit LD50 intravenous 582ug/kg (0.582mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rabbit LD50 parenteral 69420ug/kg (69.42mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rabbit LD50 rectal 162mg/kg (162mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rat LD50 intramuscular 541mg/kg (541mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rat LD50 intraperitoneal 36219ug/kg (36.219mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rat LD50 intravenous 1400ug/kg (1.4mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rat LD50 oral 675mg/kg (675mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.
rat LD50 subcutaneous > 1347mg/kg (1347mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 5, Pg. 184, 1963.