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Substance Name: Hachimycin [INN:BAN]
RN: 1394-02-1
UNII: 7073J025LS
InChIKey: RZWQQZWPVPHLSY-NCZWHYCESA-N

Classification Codes

  • Anti-Infective Agents
  • Antibiotic Produced by Streptomyces Hachijoensis
  • Antifungal Agents
  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C61-H84-N2-O20

Molecular Weight

  • 2194.5952
 
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Names and Synonyms

Name of Substance

  • Hachimycin
  • Hachimycin [INN:BAN]

Synonyms

  • Cabimicina
  • Hachimicina
  • Hachimicina [INN-Spanish]
  • Hachimycin
  • Hachimycine
  • Hachimycine [INN-French]
  • Hachimycinum
  • Hachimycinum [INN-Latin]
  • Trichomycinum
  • Trichonat
  • UNII-7073J025LS

Systematic Names

  • Antibiotic produced by Streptomyces hachijoensis, or the same substance produced by any other means
  • Trichomycin

Registry Numbers

CAS Registry Number

  • 1394-02-1

FDA UNII

  • 7073J025LS

System Generated Number

  • 0001394021

Structure Descriptors

InChI

1S/2C58H84N2O18/c1-35-17-14-12-10-8-6-4-5-7-9-11-13-15-20-46(76-57-54(71)52(60)53(70)37(3)75-57)32-49-51(56(72)73)48(68)34-58(74,78-49)33-45(66)29-44(65)28-43(64)27-40(61)18-16-19-41(62)31-50(69)77-55(35)36(2)21-26-42(63)30-47(67)38-22-24-39(59)25-23-38;1-35-17-14-12-10-8-6-4-5-7-9-11-13-15-20-46(76-57-54(71)52(60)53(70)37(3)75-57)32-49-51(56(72)73)48(68)34-58(74,78-49)33-45(66)28-41(62)19-16-18-40(61)27-43(64)29-44(65)31-50(69)77-55(35)36(2)21-26-42(63)30-47(67)38-22-24-39(59)25-23-38/h4-15,17,20,22-25,35-37,40,42-46,48-49,51-55,57,61,63-66,68,70-71,74H,16,18-19,21,26-34,59-60H2,1-3H3,(H,72,73);4-15,17,20,22-25,35-37,40-43,45-46,48-49,51-55,57,61-64,66,68,70-71,74H,16,18-19,21,26-34,59-60H2,1-3H3,(H,72,73)/b2*5-4+,8-6+,9-7+,12-10+,13-11+,17-14+,20-15+/t35?,36?,37-,40?,42?,43?,44?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?;35?,36?,37-,40?,41?,42?,43?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?/m11/s1

InChIKey

RZWQQZWPVPHLSY-NCZWHYCESA-N

Smiles

[C@@H]1([C@@H]([C@@H]([C@@H](O[C@@H]1C)OC1CC2C(C(CC(O2)(CC(CC(CC(CC(CCCC(=O)CC(=O)OC(C(C=CC=CC=CC=CC=CC=CC=C1)C)C(CCC(CC(=O)c1ccc(N)cc1)O)C)O)O)O)O)O)O)C(=O)O)O)N)O.[C@@H]1([C@@H]([C@@H]([C@@H](O[C@@H]1C)OC1CC2C(C(CC(O2)(CC(CC(CCCC(CC(CC(=O)CC(=O)OC(C(C=CC=CC=CC=CC=CC=CC=C1)C)C(CCC(CC(=O)c1ccc(N)cc1)O)C)O)O)O)O)O)O)C(=O)O)O)N)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3400ug/kg (3.4mg/kg)   Journal of Antibiotics, Series A. Vol. 11, Pg. A26, 1958.
mouse LD50 intravenous 4300units/kg (4300units/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Antibiotics, Series A. Vol. 7, Pg. 159, 1954.
mouse LD50 subcutaneous 34000units/kg (34000units/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Journal of Antibiotics, Series A. Vol. 7, Pg. 159, 1954.
mouse LDLo oral 1gm/kg (1000mg/kg)   Journal of Antibiotics, Series A. Vol. 6, Pg. 98, 1953.