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Substance Name: Guan-fu base A
RN: 1394-48-5
InChIKey: OGNUSOJAYIHLNS-CZORAKQYSA-N

Note

  • An anti-arrhythmia agent; isolated from the tuber of Aconitum doreanum.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H31-N-O6

Molecular Weight

  • 429.5099
 
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Names and Synonyms

Name of Substance

  • Guan-fu base A

Synonyms

  • BRN 5165899
  • Guan-fu base A
  • Kwan-Fu Base A

Systematic Name

  • Hetisan-2,11,13,14-tetrol, 2,11-diacetate, (2-alpha,11-alpha,13R)-

Registry Numbers

CAS Registry Number

  • 1394-48-5

System Generated Number

  • 0001394485

Structure Descriptors

InChI

1S/C24H31NO6/c1-10-5-22-8-14-17-21(4)6-13(30-11(2)26)7-23(17)18(22)16(28)15(10)19(31-12(3)27)24(22,29)20(23)25(14)9-21/h13-20,28-29H,1,5-9H2,2-4H3/t13-,14?,15+,16+,17+,18+,19?,20?,21-,22?,23-,24-/m0/s1

InChIKey

OGNUSOJAYIHLNS-CZORAKQYSA-N

Smiles

CC(=O)O[C@H]1C[C@]2(C[N@@]3C4[C@H]2[C@]5(C1)C3[C@]6(C([C@H]7[C@H]([C@@H]5C6(C4)CC7=C)O)OC(=O)C)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 421mg/kg (421mg/kg)   Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 18, Pg. 455, 1987.
mouse LD50 intravenous 134mg/kg (134mg/kg)   Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 4, Pg. 247, 1983.