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Substance Name: Retinoblastoma binding protein 1
RN: 139532-74-4


  • A ubiquitously expressed regulatory protein that contains a retinoblastoma protein binding domain and an AT-rich interactive domain. The protein may play a role in recruiting HISTONE DEACETYLASES to the site of RETINOBLASTOMA PROTEIN-containing transcriptional repressor complexes.
  • An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.
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Names and Synonyms

Name of Substance

  • Retinoblastoma binding protein 1

MeSH Headings

  • E2F1 Transcription Factor
  • Retinoblastoma-Binding Protein 1


  • Rbap-1
  • RBP-1
  • Retinoblastoma-associated protein 1

Systematic Name

  • Protein RBP 1 (human retinoblastoma-binding C-terminal fragment reduced)

Registry Numbers

CAS Registry Number

  • 139532-74-4

System Generated Number

  • 0139532744