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Substance Name: Tissue Plasminogen Activator
RN: 139639-23-9


  • A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to PLASMIN. It has fibrin-binding activity and is immunologically different from URINARY PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

Molecular Formula

  • Unspecified
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Names and Synonyms

Name of Substance

  • Tissue Plasminogen Activator

MeSH Heading

  • Tissue Plasminogen Activator


  • AK 124
  • Tissue Plasminogen Activator
  • Tissue-type plasminogen activator
  • TPA

Systematic Name

  • Plasminogen activator, tissue-type

Registry Numbers

CAS Registry Number

  • 139639-23-9

System Generated Number

  • 0139639239