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Substance Name: Actinomycin A
RN: 1397-78-0

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C41-H56-N8-O11
 
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Names and Synonyms

Synonym

  • Actinomycin B1

Systematic Name

  • Actinomycin A

Registry Numbers

CAS Registry Number

  • 1397-78-0

System Generated Number

  • 0001397780

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 250ug/kg (0.25mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 25, 1942.
mouse LDLo intravenous 250ug/kg (0.25mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 25, 1942.
mouse LDLo oral 10mg/kg (10mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: CHANGES IN SPLEEN
Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 25, 1942.
mouse LDLo subcutaneous 250ug/kg (0.25mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 25, 1942.
rabbit LDLo intravenous 1mg/kg (1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 25, 1942.