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Substance Name: Iobenguane sulfate I 123 [USAN]
RN: 139755-80-9
UNII: 23X1185WBO
InChIKey: XNACDNPGABUBFR-FKNPGSCZSA-N

Note

  • A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.

Molecular Formula

  • C16-H20-[123I]2-N6.O4S-H2

Molecular Weight

  • 640.265
 

Classification Codes

  • Antineoplastic Agents
  • Diagnostic Aid (Radioactive, Adrenomedullary Disorders and Neuroendocrine Tumors)
  • Enzyme Inhibitors
  • Radioactive Agent
  • Radiopharmaceuticals
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Names and Synonyms

Name of Substance

  • Iobenguane sulfate I 123 [USAN]

Synonyms

  • ((3-(Iodo-(sup 123)I)-phenyl)methyl)guanidine sulfate (2:1)
  • (m-Iodo-(sup 123)I)-benzyl)guanidine sulfate (2:1)
  • (m-Iodo-(sup 123)I-benzyl)guanidine sulfate (2:1)
  • Adreview
  • Guanidine, ((3-(iodo-(sup 123)I)phenyl)methyl)-, sulfate (2:1)
  • Iobenguane sulfate I 123
  • UNII-23X1185WBO

Registry Numbers

CAS Registry Number

  • 139755-80-9

FDA UNII

  • 23X1185WBO

System Generated Number

  • 0139755809

Structure Descriptors

InChI

1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)/i2*9-4;

InChIKey

XNACDNPGABUBFR-FKNPGSCZSA-N

Smiles

NC(=N)NCc1cccc([123I])c1.NC(=N)NCc2cccc([123I])c2.OS(=O)(=O)O