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Substance Name: DS-3032B
RN: 1398569-75-9
UNII: 6M27443B0N
InChIKey: NHIUKVHKLJSJEA-LINJWFRASA-N

Note

  • MDM2 inhibitor DS-3032b An orally available NCI: MDM2 (murine double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, MDM2 inhibitor DS-3032b binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it has been implicated in cancer cell proliferation and survival. (NCI Thesaurus)

Molecular Formula

  • C30-H34-Cl2-F-N5-O4.C7-H8-O3-S

Molecular Weight

  • 790.7368
 
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Names and Synonyms

Name of Substance

  • DS-3032B

Synonyms

  • DS-3032B
  • L-Erythro-hexonamide, 2,6-anhydro-5-((((3'R,4'S,5'R)-6''-chloro-4'-(2-chloro-3-fluoro-4-pyridinyl)-1'',2''-dihydro-4,4-dimethyl-2''-oxodispiro(cyclohexane-1,2'-pyrrolidine-3',3''-(3H)indol)-5'-yl)carbonyl)amino)-3,4,5-trideoxy-, 4-methylbenzenesulfon
  • UNII-6M27443B0N

Registry Numbers

CAS Registry Number

  • 1398569-75-9

FDA UNII

  • 6M27443B0N

System Generated Number

  • 1398569759

Structure Descriptors

InChI

1S/C30H34Cl2FN5O4.C7H8O3S/c1-28(2)8-10-29(11-9-28)30(18-5-3-15(31)13-19(18)37-27(30)41)21(17-7-12-35-24(32)22(17)33)23(38-29)26(40)36-16-4-6-20(25(34)39)42-14-16;1-6-2-4-7(5-3-6)11(8,9)10/h3,5,7,12-13,16,20-21,23,38H,4,6,8-11,14H2,1-2H3,(H2,34,39)(H,36,40)(H,37,41);2-5H,1H3,(H,8,9,10)/t16-,20+,21+,23-,30-;/m1./s1

InChIKey

NHIUKVHKLJSJEA-LINJWFRASA-N

Smiles

Cc1ccc(cc1)S(=O)(=O)O.CC2(C)CCC3(CC2)N[C@H]([C@H](c4ccnc(Cl)c4F)[C@]35C(=O)Nc6cc(Cl)ccc56)C(=O)N[C@@H]7CC[C@H](OC7)C(=O)N