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Substance Name: Metiazinic acid [INN:DCF:JAN]
RN: 13993-65-2
UNII: 12I0HHE2ZY
InChIKey: LMINNBXUMGNKMM-UHFFFAOYSA-N

Note

  • Phenothiazine which acts as an anti-inflammatory agent.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C15-H13-N-O2-S

Molecular Weight

  • 271.3387
 
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Names and Synonyms

Name of Substance

  • Metiazinic acid
  • Metiazinic acid [INN:DCF:JAN]

Synonyms

  • (10-Methyl-2-phenothiazinyl)acetic acid
  • 10-Methylphenothiazine-2-acetic acid
  • 2-(10-Methyl-2-phenothiazinyl)essigsaeure
  • Acide metiazinique
  • Acide metiazinique [French]
  • Acide metiazinique [INN-French]
  • Acido metiazinico
  • Acido metiazinico [INN-Spanish]
  • Acidum metiazinicum
  • Acidum metiazinicum [INN-Latin]
  • Ambrunate
  • Bayer 4512
  • EINECS 237-795-0
  • Methiazinic acid
  • Metiazinic acid
  • N-Methyl-3-phenothiazinylacetic acid
  • Roimal
  • RP 16,091
  • RP 16091
  • Soridermal
  • Soripal
  • UNII-12I0HHE2ZY

Systematic Names

  • 10-Methylphenothiazine-2-acetic acid
  • Metiazinic acid
  • Phenothiazine-2-acetic acid, 10-methyl-

Registry Numbers

CAS Registry Number

  • 13993-65-2

FDA UNII

  • 12I0HHE2ZY

System Generated Number

  • 0013993652

Structure Descriptors

InChI

1S/C15H13NO2S/c1-16-11-4-2-3-5-13(11)19-14-7-6-10(8-12(14)16)9-15(17)18/h2-8H,9H2,1H3,(H,17,18)

InChIKey

LMINNBXUMGNKMM-UHFFFAOYSA-N

Smiles

CN1c2ccccc2Sc3c1cc(cc3)CC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 2gm/kg (2000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1207, 1969.
guinea pig LD50 oral 225mg/kg (225mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1207, 1969.
mouse LD50 intraperitoneal 350mg/kg (350mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 429, 1975.
mouse LD50 intravenous 350mg/kg (350mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1198, 1969.
mouse LD50 oral 800mg/kg (800mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1198, 1969.
mouse LD50 subcutaneous 490mg/kg (490mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1207, 1969.
rat LD50 intraperitoneal 365mg/kg (365mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 429, 1975.
rat LD50 oral 495mg/kg (495mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1535, 1974.
rat LD50 subcutaneous 405mg/kg (405mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1535, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 144 deg C   EXP
log P (octanol-water) 3.810 (none)   EST
Water Solubility 31 mg/L 30 EXP
Atmospheric OH Rate Constant 2.02E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.