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Substance Name: Nithiamide [USAN]
RN: 140-40-9
UNII: 9CBM60191Z
InChIKey: UJRRDDHEMZLWFI-UHFFFAOYSA-N

Classification Codes

  • Antibacterial (Veterinary)
  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C5-H5-N3-O3-S

Molecular Weight

  • 187.178
 
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Names and Synonyms

Name of Substance

  • Aminitrozole [INN]
  • Nithiamide
  • Nithiamide [USAN]

Synonyms

  • 2-Acetamido-5-nitrothiazole
  • 4-27-00-04676 (Beilstein Handbook Reference)
  • 5-Nitro-2-acetamidothiazole
  • 5-Nitro-2-acetilaminotiazolo
  • 5-Nitro-2-acetilaminotiazolo [Italian]
  • Acetamide, N-(5-nitro-2-thiazolyl)-
  • Acetyl enheptin
  • Acinitrazole
  • Ametoterina
  • Aminitrazol
  • Aminitrozol
  • Aminitrozole
  • Aminitrozolum
  • Aminitrozolum [INN-Latin]
  • Amminitrozol
  • Amminitrozol [INN-Spanish, French]
  • BRN 0167361
  • CL 5,279
  • CL 5279
  • Cyzine premix
  • EINECS 205-414-7
  • Enheptin A
  • Gynofon
  • Lavoflagin
  • N-(5-Nitro-2-thiazolyl)acetamide
  • Nitasol
  • Nitazol
  • Nitazole
  • Nithiamide
  • NSC 31539
  • NSC 45914
  • Pleocide
  • RP 8243
  • Torion
  • Trichlorad
  • Trichocid
  • Trichoman
  • Trichorad
  • Trichoral
  • Tricogen
  • Tricolaval
  • Tricoral
  • Tricosil
  • Tricosteril
  • Trikolaval
  • Tritheon
  • UNII-9CBM60191Z

Systematic Names

  • 2-Acetamido-5-nitrothiazole
  • Acetamide, N-(5-nitro-2-thiazolyl)-
  • Aminitrozole
  • Thiazole, 2-acetamido-5-nitro-

Registry Numbers

CAS Registry Number

  • 140-40-9

FDA UNII

  • 9CBM60191Z

System Generated Number

  • 0000140409

Structure Descriptors

InChI

1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)

InChIKey

UJRRDDHEMZLWFI-UHFFFAOYSA-N

Smiles

c1(sc([N+]([O-])=O)cn1)NC(C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 800mg/kg (800mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
dog LD50 oral 125mg/kg (125mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
dog LD50 oral 125mg/kg (125mg/kg) BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
mouse LD subcutaneous > 3200mg/kg (3200mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
mouse LD50 intraperitoneal > 300mg/kg (300mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
mouse LD50 oral 200mg/kg (200mg/kg)   British Patent Document. Vol. #1229170,
rat LD subcutaneous > 3200mg/kg (3200mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
rat LD50 intraperitoneal > 200mg/kg (200mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
rat LD50 oral > 400mg/kg (400mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
turkey LD50 oral 600mg/kg (600mg/kg)   Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 264.5 deg C   EXP
log P (octanol-water) 1.3 (none)   EXP
Water Solubility 1610 mg/L 25 EST
Vapor Pressure 1.86E-06 mm Hg 25 EST
Henry's Law Constant 1.73E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.66E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.