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Substance Name: Nystatin [USP:INN:BAN:JAN]
RN: 1400-61-9
UNII: BDF1O1C72E
InChIKey: VQOXZBDYSJBXMA-RKEBNKJGSA-N
Note
- Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
Molecular Formulas
- C46-H83-N-O18
- C47-H75-N-O17
- Unspecified
Molecular Weight
- 926.099
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antifungal
- Antifungal Agents
- Drug / Therapeutic Agent
- Ionophores
- Membrane Transport Modulators
- Mutation Data
- Natural Product
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Nystatin
- Nystatin [USP:INN:BAN:JAN]
MeSH Heading
- Nystatin
Synonyms
- AI3-26526
- Barstatin 100
- Biofanal
- Candex
- Candex Lotion
- Candio-hermal
- Caswell No. 607B
- Diastatin
- EINECS 215-749-0
- EPA Pesticide Chemical Code 202800
- Fungicidin
- Herniocid
- HSDB 3138
- Korostatin
- Moronal
- Moronal (antibiotic)
- Myconystatin
- Mycostatin
- Mycostatin 20
- Mycostatin Pastilles
- Mykinac
- Mykostatyna
- Nilstat
- Nistatin
- Nistatina
- Nistatina [INN-Spanish]
- NSC 150817
- Nyamyc
- Nyotran
- Nysert
- Nystan
- Nystatin
- Nystatin A1, A2, A3 complex
- Nystatin LF (liposome)
- Nystatine
- Nystatine [INN-French]
- Nystatinum
- Nystatinum [INN-Latin]
- Nystatyna
- Nystatyna [Polish]
- Nystavescent
- Nystex
- Nystop
- O-V Statin
- Stamycin
- UNII-BDF1O1C72E
- Zydin E
Systematic Name
- Nystatin
Mixture Names
- Comycin
- Myco-Triacet II
- Mycolog II
- Mytrex
- Nystaform
- Nystaform-HC
- Panolog Cream (Veterinary)
- Terrastatin
Registry Numbers
CAS Registry Number
- 1400-61-9
FDA UNII
- BDF1O1C72E
System Generated Number
- 0001400619
Structure Descriptors
InChI
InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1InChIKey
VQOXZBDYSJBXMA-RKEBNKJGSA-NSmiles
C[C@@H]1OC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 4400ug/kg (4.4mg/kg) | Journal of Pharmaceutical Sciences. Vol. 65, Pg. 905, 1976. | |
mouse | LD50 | intravenous | 3mg/kg (3mg/kg) | Journal of Antibiotics. Vol. 32, Pg. 1230, 1979. | |
mouse | LD50 | oral | 8gm/kg (8000mg/kg) | Progress in Medical Chemistry. Vol. 14, Pg. 105, 1977. | |
mouse | LD50 | subcutaneous | 120mg/kg (120mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 228S, 1957. | |
rat | LD50 | intraperitoneal | 24305ug/kg (24.305mg/kg) | Antibiotics Annual. Vol. 3, Pg. 697, 1955/1956. | |
rat | LD50 | oral | 10gm/kg (10000mg/kg) | Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 30, Pg. 81, 1973. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 7.080 | (none) | EST | |
Water Solubility | 360 | mg/L | 24 | EXP |
Atmospheric OH Rate Constant | 2.52E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.