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Substance Name: Tannic acid [USP:JAN]
RN: 1401-55-4
UNII: 28F9E0DJY6
InChIKey: LRBQNJMCXXYXIU-QWKBTXIPSA-N

Notes

  • Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
  • TSCA Definition 2017: Gallic acid derivatives found in nutgalls, bark and other plant parts, especially oak bark.

Molecular Formulas

  • C76-H52-O46
  • Unspecified

Molecular Weight

  • 1701.2008
 

Classification Codes

Classification Codes

  • Astringent
  • Mutation Data
  • Natural Product
  • Reproductive Effect
  • TSCA UVCB
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms

Name of Substance

  • Tannic acid
  • Tannic acid [USP:JAN]

MeSH Heading

  • Tannins

Synonyms

  • Acacia mollissima tannin
  • Acid, tannic
  • Acide tannique
  • Acide tannique [French]
  • Castanea sativa Mill tannin
  • Caswell No. 819
  • CCRIS 571
  • d'Acide tannique
  • d'Acide tannique [French]
  • EINECS 215-753-2
  • EPA Pesticide Chemical Code 078502
  • FEMA No. 3042
  • Gallotannic acid
  • Gallotannin
  • Glycerite
  • HSDB 831
  • Liquidambar styraciflua
  • NSC 656273
  • Quebracho wood extract
  • Schinopsis lorentzii tannin
  • Tannic acid
  • Tannic acid (Quercus spp.)
  • Tannic acid; Tannin
  • Tannin
  • Tannin from chestnut
  • Tannin from mimosa
  • Tannin from quebracho
  • Tannin from sweet gum
  • Tannins
  • UNII-28F9E0DJY6

Systematic Names

  • Chestnut tannin
  • Mimosa tannin
  • Quebracho tannin
  • Sweet gum
  • Tannic acid
  • Tannin
  • Tannins

Superlist Names

  • Hydrolyzable gallotannin
  • Quebracho extract
  • Tannic acid
  • Tannic acid and tannins
  • Tannins

Registry Numbers

CAS Registry Number

  • 1401-55-4

FDA UNII

  • 28F9E0DJY6

Other Registry Numbers

  • 1041198-33-7
  • 1041198-44-0
  • 61790-06-5
  • 67167-65-1
  • 73891-88-0
  • 93615-37-3

System Generated Number

  • 0001401554

Structure Descriptors

InChI

1S/C76H52O46/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26/h1-20,52,63-65,76-101H,21H2/t52-,63-,64+,65-,76+/m0/s1

InChIKey

LRBQNJMCXXYXIU-QWKBTXIPSA-N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
domestic animals - goat/sheep LDLo intraperitoneal 1gm/kg (1000mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Research in Veterinary Science. Vol. 53, Pg. 280, 1992.
domestic animals - goat/sheep LDLo oral 1gm/kg (1000mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Veterinary and Human Toxicology. Vol. 37, Pg. 50, 1995.
guinea pig LDLo intravenous 40mg/kg (40mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 571, 1969.
mouse LD50 intramuscular 120mg/kg (120mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intramuscular 350mg/kg (350mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intramuscular > 1600mg/kg (1600mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intramuscular > 1600mg/kg (1600mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intraperitoneal 120mg/kg (120mg/kg)   Planta Medica. Vol. 52, Pg. 272, 1986.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intraperitoneal 320mg/kg (320mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intraperitoneal 360mg/kg (360mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intravenous 50mg/kg (50mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intravenous 130mg/kg (130mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 intravenous 130mg/kg (130mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 subcutaneous 140mg/kg (140mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 subcutaneous > 1600mg/kg (1600mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LD50 subcutaneous > 1600mg/kg (1600mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
mouse LDLo intravenous 10mg/kg (10mg/kg) SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 63, 1943.
mouse LDLo oral 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 63, 1943.
mouse LDLo subcutaneous 75mg/kg (75mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 63, 1943.
rabbit LD50 oral 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

GASTROINTESTINAL: GASTRITIS
American Journal of Veterinary Research. Vol. 23, Pg. 1264, 1962.
rat LD50 oral 2260mg/kg (2260mg/kg) GASTROINTESTINAL: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 571, 1969.
rat LDLo parenteral 1400mg/kg (1400mg/kg)   Food and Cosmetics Toxicology. Vol. 14, Pg. 565, 1976.
rat LDLo subcutaneous 200mg/kg (200mg/kg)   Wiener Klinische Wochenschrift. Vol. 62, Pg. 270, 1950.