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Substance Name: Neomycin [INN:BAN]
RN: 1404-04-2
UNII: I16QD7X297
InChIKey: PGBHMTALBVVCIT-VCIWKGPPSA-N
Note
- Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis.
Molecular Formula
- Unspecified
Molecular Weight
- 614.645
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Mutation Data
- Natural Product
- Protein Synthesis Inhibitors
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Names and Synonyms
Name of Substance
- Neomycin
- Neomycin [INN:BAN]
MeSH Heading
- Neomycin
Synonyms
- Bycomycin
- Caswell No. 595
- CCRIS 5462
- EINECS 215-766-3
- EPA Pesticide Chemical Code 006303
- Fradiomycin
- Fradiomycinum
- HSDB 3242
- Jernadex
- Myacyne
- Mycifradin
- Neolate
- Neomas
- Neomcin
- Neomicina
- Neomicina [DCIT]
- Neomin
- Neomycin
- Neomycine
- Neomycine [INN-French]
- Neomycinum
- Neomycinum [INN-Latin]
- Nivemycin
- Pimavecort
- UNII-I16QD7X297
- Vonamycin powder V
Systematic Name
- Neomycin
Registry Numbers
CAS Registry Number
- 1404-04-2
FDA UNII
- I16QD7X297
Other Registry Number
- 11013-50-6
Related Registry Number
- 1405-10-3 (sulfate (salt))
System Generated Number
- 0001404042
Structure Descriptors
InChI
InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1InChIKey
PGBHMTALBVVCIT-VCIWKGPPSA-NSmiles
NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | unreported | 57mg/kg (57mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGES IN COCHLEAR STRUCTURE OR FUNCTION: EAR KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Annals of Internal Medicine. Vol. 66, Pg. 1052, 1967. |
mouse | LD50 | intraperitoneal | 116mg/kg (116mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 664, 1978. | |
mouse | LD50 | intravenous | 27600ug/kg (27.6mg/kg) | Antibiotiki. Vol. 21, Pg. 532, 1976. | |
mouse | LD50 | oral | 2880mg/kg (2880mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 664, 1978. | |
mouse | LD50 | subcutaneous | 275mg/kg (275mg/kg) | Antibiotiki. Vol. 17, Pg. 522, 1972. | |
rat | LD50 | oral | 2750mg/kg (2750mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
rat | LD50 | subcutaneous | 633mg/kg (633mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 176, Pg. 59, 1968. | |
women | TDLo | oral | 220mg/kg/2D (220mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Laryngoscope. Vol. 78, Pg. 1734, 1968. |