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Substance Name: Polymyxin A
RN: 1404-24-6

Classification Code

  • Drug / Therapeutic Agent
 
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Names and Synonyms

Synonym

  • Polymixin A

Systematic Name

  • Polymyxin A

Registry Numbers

CAS Registry Number

  • 1404-24-6

System Generated Number

  • 0001404246

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 88mg/kg (88mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1542, 1978.
mouse LDLo intraperitoneal 13mg/kg (13mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Lancet. Vol. 254, Pg. 127, 1948.
mouse LDLo intravenous 6mg/kg (6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: MUSCLE WEAKNESS
Lancet. Vol. 254, Pg. 127, 1948.
rabbit LDLo intracrebral 600ug/kg (0.6mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 51, Pg. 952, 1949.