Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Polymyxin B [INN]
RN: 1404-26-8
UNII: J2VZ07J96K
InChIKey: ZBJNZFQKYZCUJU-DVCWYZLXSA-N

Note

  • A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Molecular Formula

  • C43-H82-N16-O12

Molecular Weight

  • 2392.9516
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Results Name

  • Polymyxin B [INN]

Name of Substance

  • Polymyxin B
  • Polymyxin b [INN:BAN]
  • Polymyxin B [INN]

MeSH Heading

  • Polymyxin B

Synonyms

  • Aerosporin
  • EINECS 215-768-4
  • Polimixina B
  • Polimixina B [INN-Spanish]
  • Polymixin B
  • Polymyxin B
  • Polymyxine B
  • Polymyxine B [INN-French]
  • Polymyxinum B
  • Polymyxinum B [INN-Latin]
  • UNII-J2VZ07J96K

Systematic Name

  • Polymyxin B

Registry Numbers

CAS Registry Number

  • 1404-26-8

FDA UNII

  • J2VZ07J96K

System Generated Number

  • 0001404268

Structure Descriptors

InChI

1S/C56H98N16O13.C55H96N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-30(2)12-10-11-15-43(74)62-35(16-22-56)50(79)71-45(33(6)73)55(84)67-38(19-25-59)47(76)66-40-21-27-61-54(83)44(32(5)72)70-51(80)39(20-26-60)64-46(75)36(17-23-57)65-52(81)41(28-31(3)4)68-53(82)42(29-34-13-8-7-9-14-34)69-48(77)37(18-24-58)63-49(40)78/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);7-9,13-14,30-33,35-42,44-45,72-73H,10-12,15-29,56-60H2,1-6H3,(H,61,83)(H,62,74)(H,63,78)(H,64,75)(H,65,81)(H,66,76)(H,67,84)(H,68,82)(H,69,77)(H,70,80)(H,71,79)/t32?,33-,34?,36+,37+,38+,39+,40+,41+,42+,43-,45+,46+;32-,33?,35+,36+,37+,38+,39+,40+,41+,42-,44+,45+/m11/s1

InChIKey

ZBJNZFQKYZCUJU-DVCWYZLXSA-N

Smiles

CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)Cc2ccccc2)CC(C)C)CCN)CCN)[C@@H](C)O.C[C@H]([C@H]1C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCN)CCN)CC(C)C)Cc2ccccc2)CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](C(C)O)NC(=O)[C@H](CCN)NC(=O)CCCCC(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intramuscular 3mg/kg/D (3mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: ATAXIA
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 488, 1969.
human TDLo oral 8570mg/kg (8570mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 488, 1969.
mouse LD50 intramuscular 61400ug/kg (61.4mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Antibiotiki. Vol. 21, Pg. 846, 1976.
mouse LD50 intravenous 3980ug/kg (3.98mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Antibiotiki. Vol. 21, Pg. 846, 1976.
mouse LDLo intraperitoneal 13mg/kg (13mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS
Lancet. Vol. 254, Pg. 127, 1948.
rat LD50 intramuscular 13300ug/kg (13.3mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Antibiotiki. Vol. 21, Pg. 846, 1976.
rat LD50 subcutaneous 50mg/kg (50mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 215, 1955.