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Substance Name: Ristocetin [USP:INN:BAN]
RN: 1404-55-3
UNII: ZP3E6S00IL
InChIKey: VUOPFFVAZTUEGW-FBMDODLCSA-N

Note

  • An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.

Molecular Formula

  • Unspecified

Molecular Weight

  • 2067.926
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Natural Product
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Names and Synonyms

Name of Substance

  • Ristocetin
  • Ristocetin [USP:INN:BAN]

MeSH Heading

  • Ristocetin

Synonyms

  • EINECS 215-770-5
  • Ristocetin
  • Ristocetina
  • Ristocetina [INN-Spanish]
  • Spontin
  • UNII-ZP3E6S00IL

Systematic Names

  • Antibiotic obtained from cultures of Nocardia lurida, or the same substance produced by any other means
  • Ristocetin

Registry Numbers

CAS Registry Number

  • 1404-55-3

FDA UNII

  • ZP3E6S00IL

System Generated Number

  • 0001404553

Structure Descriptors

InChI

1S/C95H110N8O44/c1-30-47(109)18-37-20-49(30)139-50-19-35(9-16-46(50)108)59(97)84(125)102-64-68(113)33-5-11-40(12-6-33)137-52-21-38-22-53(81(52)145-95-83(76(121)72(117)56(143-95)29-134-91-78(123)73(118)67(112)32(3)136-91)147-94-82(75(120)71(116)55(27-105)142-94)146-92-77(122)69(114)48(110)28-133-92)138-41-13-7-34(8-14-41)80(144-57-25-44(96)66(111)31(2)135-57)65-89(130)101-63(90(131)132-4)43-23-39(106)24-51(140-93-79(124)74(119)70(115)54(26-104)141-93)58(43)42-17-36(10-15-45(42)107)60(85(126)103-65)98-87(128)62(38)99-86(127)61(37)100-88(64)129/h5-24,31-32,44,48,54-57,59-80,82-83,91-95,104-124H,25-29,96-97H2,1-4H3,(H,98,128)(H,99,127)(H,100,129)(H,101,130)(H,102,125)(H,103,126)/t31-,32-,44+,48+,54+,55-,56+,57+,59+,60+,61-,62+,63-,64+,65-,66-,67-,68+,69+,70+,71-,72+,73+,74-,75+,76-,77-,78+,79-,80+,82+,83+,91?,92-,93+,94-,95-/m0/s1

InChIKey

VUOPFFVAZTUEGW-FBMDODLCSA-N

Smiles

O([C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@@H]1O)CO)c1cc(cc2[C@@H](C(=O)OC)NC(=O)[C@@H]3[C@H](O[C@@H]4C[C@H]([C@H]([C@@H](O4)C)O)N)c4ccc(Oc5cc6[C@@H](NC(=O)[C@@H]7c8cc(c(c(c8)Oc8cc(ccc8O)[C@H](C(=O)N[C@@H](C(=O)N7)[C@@H](c7ccc(cc7)Oc(c6)c5O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)CO)O)O)O[C@@H]5OC[C@H]([C@H]([C@@H]5O)O)O)O)O)COC5O[C@H]([C@@H]([C@H]([C@H]5O)O)O)C)O)N)C)O)C(=O)N[C@H](c5cc(c(cc5)O)c12)C(=O)N3)cc4)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous > 500mg/kg (500mg/kg)   Antibiotics Annual. Vol. 4, Pg. 687, 1956/1957.