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Substance Name: Tyrothricin [USP:INN:BAN]
RN: 1404-88-2
UNII: 877376V2XW
InChIKey: NLJVXZFCYKWXLH-DXTIXLATSA-N
Note
- A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.
Molecular Formula
- Unspecified
Molecular Weight
- 1228.4505
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antibacterial
- Drug / Therapeutic Agent
- Mutation Data
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Names and Synonyms
Name of Substance
- Tyrothricin
- Tyrothricin [USP:INN:BAN]
MeSH Heading
- Tyrothricin
Synonyms
- Bactratycin
- Biothricin
- Caswell No. 900A
- Coltirot
- Dermotricine
- Dubos crude crystals
- EINECS 215-771-0
- EPA Pesticide Chemical Code 006311
- Ginotricina
- Hydrotricine
- Intraderm tyrothricin
- Martricin
- NSC 757363
- Pharothricetten
- Rinotricina
- Solutricine
- Tirotricina
- Tirotricina [INN-Spanish]
- Triciderm
- Tyrex
- Tyri 10
- Tyroderm
- Tyrosur
- Tyrothricin
- Tyrothricine
- Tyrothricine [INN-French]
- Tyrothricinum
- Tyrothricinum [INN-Latin]
- Tyrozets
- UNII-877376V2XW
Systematic Names
- An antibacterial substance produced by the growth of Bacillus brevis Dubos (Fam. Bacteriaceae)
- Tyrothricin
Mixture Name
- Otalgine
Registry Numbers
CAS Registry Number
- 1404-88-2
FDA UNII
- 877376V2XW
System Generated Number
- 0001404882
Structure Descriptors
InChI
InChI=1S/C65H85N11O13/c1-38(2)32-49-60(84)74-52(36-42-20-12-7-13-21-42)65(89)76-31-15-23-53(76)63(87)73-51(34-41-18-10-6-11-19-41)61(85)70-47(33-40-16-8-5-9-17-40)57(81)48(37-54(67)78)71-59(83)46(28-29-55(79)80)68-50(35-43-24-26-44(77)27-25-43)62(86)75-56(39(3)4)64(88)69-45(22-14-30-66)58(82)72-49/h5-13,16-21,24-27,38-39,45-53,56,68,77H,14-15,22-23,28-37,66H2,1-4H3,(H2,67,78)(H,69,88)(H,70,85)(H,71,83)(H,72,82)(H,73,87)(H,74,84)(H,75,86)(H,79,80)/t45-,46-,47+,48-,49-,50-,51-,52+,53-,56-/m0/s1InChIKey
NLJVXZFCYKWXLH-DXTIXLATSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957. | |
mouse | LD50 | oral | > 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957. | |
mouse | LD50 | subcutaneous | > 1500mg/kg (1500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957. | |
mouse | LDLo | intravenous | 1200ug/kg (1.2mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 75, 1942. |