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Substance Name: Tyrothricin [USP:INN:BAN]
RN: 1404-88-2
UNII: 877376V2XW
InChIKey: NLJVXZFCYKWXLH-DXTIXLATSA-N

Note

  • A polypeptide antibiotic mixture obtained from Bacillus brevis. It consists of a mixture of three tyrocidines (60%) and several gramicidins (20%) and is very toxic to blood, liver, kidneys, meninges, and the olfactory apparatus. It is used topically.

Molecular Formula

  • Unspecified

Molecular Weight

  • 1228.4505
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Antibacterial
  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Tyrothricin
  • Tyrothricin [USP:INN:BAN]

MeSH Heading

  • Tyrothricin

Synonyms

  • Bactratycin
  • Biothricin
  • Caswell No. 900A
  • Coltirot
  • Dermotricine
  • Dubos crude crystals
  • EINECS 215-771-0
  • EPA Pesticide Chemical Code 006311
  • Ginotricina
  • Hydrotricine
  • Intraderm tyrothricin
  • Martricin
  • Pharothricetten
  • Rinotricina
  • Solutricine
  • Tirotricina
  • Tirotricina [INN-Spanish]
  • Triciderm
  • Tyrex
  • Tyri 10
  • Tyroderm
  • Tyrosur
  • Tyrothricin
  • Tyrothricine
  • Tyrothricine [INN-French]
  • Tyrothricinum
  • Tyrothricinum [INN-Latin]
  • Tyrozets
  • UNII-877376V2XW

Systematic Names

  • An antibacterial substance produced by the growth of Bacillus brevis Dubos (Fam. Bacteriaceae)
  • Tyrothricin

Mixture Name

  • Otalgine

Registry Numbers

CAS Registry Number

  • 1404-88-2

FDA UNII

  • 877376V2XW

System Generated Number

  • 0001404882

Structure Descriptors

InChI

1S/C65H85N11O13/c1-38(2)32-49-60(84)74-52(36-42-20-12-7-13-21-42)65(89)76-31-15-23-53(76)63(87)73-51(34-41-18-10-6-11-19-41)61(85)70-47(33-40-16-8-5-9-17-40)57(81)48(37-54(67)78)71-59(83)46(28-29-55(79)80)68-50(35-43-24-26-44(77)27-25-43)62(86)75-56(39(3)4)64(88)69-45(22-14-30-66)58(82)72-49/h5-13,16-21,24-27,38-39,45-53,56,68,77H,14-15,22-23,28-37,66H2,1-4H3,(H2,67,78)(H,69,88)(H,70,85)(H,71,83)(H,72,82)(H,73,87)(H,74,84)(H,75,86)(H,79,80)/t45-,46-,47+,48-,49-,50-,51-,52+,53-,56-/m0/s1

InChIKey

NLJVXZFCYKWXLH-DXTIXLATSA-N

Smiles

c1ccccc1C[C@@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(=O)[C@@H](NC(=O)[C@@H](N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(C)C)CCCN)[C@H](C)C)CCC(=O)O)CC(=O)N)Cc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957.
mouse LD50 oral > 3gm/kg (3000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957.
mouse LD50 subcutaneous > 1500mg/kg (1500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957.
mouse LDLo intravenous 1200ug/kg (1.2mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 75, 1942.