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Substance Name: Vancomycin hydrochloride [USP:JAN]
RN: 1404-93-9
UNII: 71WO621TJD
InChIKey: LCTORFDMHNKUSG-XTTLPDOESA-N
Note
- Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
Molecular Formula
- C66-H75-Cl2-N9-O24.Cl-H
Molecular Weight
- 1485.7244
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antibacterial
- Drug / Therapeutic Agent
- Human Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Vancomycin hydrochloride [USP:JAN]
Synonyms
- (3S-(3R*,6S*(S*),7S*,22S*,23R*,26R*,36S*,38aS*))-3-(2-Amino-2-oxoethyl)-44-((2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-((4-methyl-2-(methylamino)-1-oxopentyl)amino)-2,5,24,38,39-pentaoxo-22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-(1,6,9)oxadiazacyclohexadecino(4,5-m)(10,2,16)benzoxadiazacyclotetracosine-26-carboxylic acid, monohydrochloride
- AeroVanc
- NSC 757377
- UNII-71WO621TJD
- Vancocin hydrochloride
- Vancocin hydrochloride in plastic container
- Vancocine hydrochloride
- Vancoled
- Vancomycin HCl
- Vancomycin hydrochloride
- Vancomycin hydrochloride in a plastic container
- Vancomycin monohydrochloride
- Vancor
Systematic Names
- Vancomycin, hydrochloride
- Vancomycin, monohydrochloride
Registry Numbers
CAS Registry Number
- 1404-93-9
FDA UNII
- 71WO621TJD
Related Registry Number
- 1404-90-6 (Parent)
System Generated Number
- 0001404939
Molecular Formulas
Molecular Formula
- C66-H75-Cl2-N9-O24.Cl-H
Molecular Formula Fragments
- C66-H75-Cl2-N9-O24
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1InChIKey
LCTORFDMHNKUSG-XTTLPDOESA-NSmiles
Cl.CN[C@H](CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | intravenous | 27500ug/kg/10 (27.5mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Clinical Pediatrics Vol. 23, Pg. 416, 1984. |
guinea pig | LD50 | intraperitoneal | 737mg/kg (737mg/kg) | KIDNEY, URETER, AND BLADDER: HEMATURIA | Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957. |
man | LDLo | intravenous | 43mg/kg/2W-I (43mg/kg) | BLOOD: AGRANULOCYTOSIS | American Journal of Medicine. Vol. 81, Pg. 1059, 1986. |
man | TDLo | intravenous | 1429ug/kg/10- (1.429mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Mayo Clinic Proceedings. Vol. 61, Pg. 721, 1986. |
mouse | LD50 | intraperitoneal | 1734mg/kg (1734mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
mouse | LD50 | intravenous | 489mg/kg (489mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957. | |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957. |
rat | LD50 | intraperitoneal | 2218mg/kg (2218mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
rat | LD50 | intravenous | 319mg/kg (319mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 597, 1982. | |
women | TDLo | intraperitoneal | 40mg/kg (40mg/kg) | BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT GASTROINTESTINAL: PERITONITIS | American Journal of Kidney Diseases. Vol. 17, Pg. 76, 1991. |
women | TDLo | intravenous | 20mg/kg (20mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Annals of Internal Medicine. Vol. 101, Pg. 880, 1984. |