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Substance Name: Neomycin sulfate [USP]
RN: 1405-10-3
UNII: 057Y626693
InChIKey: OIXVKQDWLFHVGR-GQTDVWSESA-N

Note

  • Antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.

Molecular Formula

  • H2-O4-S.x-Unspecified

Molecular Weight

  • 712.723
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Neomycin sulfate [USP]

Synonyms

  • Biosol (Veterinary)
  • Bykomycin
  • Caswell No. 595A
  • EINECS 215-773-1
  • EPA Pesticide Chemical Code 006313
  • Fradiomycin sulfate
  • Lidamycin creme
  • Mycaifradin sulfate
  • Mycifradin
  • Mycifradin-N
  • Mycigient
  • Myciguent
  • Neo-fradin
  • Neo-mantle creme
  • Neo-RX
  • Neobiotic
  • Neofracin
  • Neomix
  • Neomix (Veterinary)
  • Neomycin sulfate
  • Neomycin sulphate
  • Neomycine sulfate
  • Neomycins sulfate
  • Neovet 325
  • New France F
  • Otobiotic
  • Quintess-N
  • UNII-057Y626693
  • USAF CB-19

Systematic Names

  • Neomycin sulfate
  • Neomycin, sulfate (salt)

Superlist Names

  • Neomycin sulfate
  • Neomycin sulfate (internal use)

Mixture Names

  • Campho-Phenique Antibiotic Plus Pain Relief Ointment
  • Coly-Mycin S Otic
  • Cordran-N
  • Cortisporin
  • Dexacidin
  • Drotic
  • Intromycin
  • Maxitrol
  • Neo-Cort-Dome
  • Neo-Cortef
  • Neo-Delta-Cortef
  • Neo-fradin
  • Neo-Medrol
  • Neo-Polycin
  • Neo-sol 50
  • Neo-Synalar
  • Neobacimyx (Veterinary)
  • Neobacimyx-H (Veterinary)
  • Neodecadron
  • NEOMED 325
  • Neomycin 325
  • Neosone
  • Neosporin
  • Neosporin Plus
  • Otic-Neo-Cort-Dome
  • Otocort
  • Panolog Cream (Veterinary)
  • Pediotic Suspension
  • Poly-Pred
  • Protef
  • Spectrocin
  • Statrol
  • Tresaderm (Veterinary)

Registry Numbers

CAS Registry Number

  • 1405-10-3

FDA UNII

  • 057Y626693

Other Registry Numbers

  • 124847-89-8
  • 125863-87-8
  • 126663-40-9
  • 126683-25-8
  • 127085-47-6
  • 12710-33-7
  • 1339-25-9
  • 37318-28-8
  • 56571-68-7
  • 57866-39-4
  • 60799-77-1
  • 63626-34-6
  • 8013-33-0
  • 8057-38-3

Related Registry Number

  • 1404-04-2 (Parent)

System Generated Number

  • 0001405103

Molecular Formulas

Molecular Formula

  • H2-O4-S.x-Unspecified

Molecular Formula Fragments

  • COMPONENT
  • H2-O4-S
  • Unspecified

Structure Descriptors

InChI

1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22?,23+;/m1./s1

InChIKey

OIXVKQDWLFHVGR-GQTDVWSESA-N

Smiles

O([C@H]1[C@H](O[C@H]2[C@@H]([C@H](O[C@@H]3O[C@H]([C@@H](O)[C@@H]([C@H]3N)O)CN)[C@H](O2)CO)O)[C@H]([C@H](N)C[C@@H]1N)O)[C@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1N)O)CN.S(O)(O)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intramuscular > 250mg/kg (250mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR Toxicology and Applied Pharmacology. Vol. 33, Pg. 320, 1975.
mouse LD50 intracrebral 32mg/kg (32mg/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 361, 1965.
mouse LD50 intramuscular 142mg/kg (142mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Internal Medicine. Vol. 119, Pg. 493, 1967.
mouse LD50 intraperitoneal 305mg/kg (305mg/kg)   Antibiotics and Chemotherapy Vol. 8, Pg. 198, 1958.
mouse LD50 intravenous 17400ug/kg (17.4mg/kg)   Archivum Immunologiae et Therapiae Experimentalis. Vol. 10, Pg. 947, 1962.
mouse LD50 oral > 8gm(base)/kg (8000mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 138, 1963.
mouse LD50 subcutaneous 190mg/kg (190mg/kg)   Antibiotiki. Vol. 18, Pg. 444, 1973.
rat LD50 subcutaneous 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 597, 1962.
women TDLo oral 12600mg/kg/7D (12600mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives of Surgery Vol. 111, Pg. 822, 1976.