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Substance Name: Polymyxin B sulfate [USP:JAN]
RN: 1405-20-5
UNII: 19371312D4
InChIKey: HNDFYNOVSOOGDU-UHFFFAOYSA-N

Note

  • A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Molecular Formula

  • C43-H82-N16-O12.x-H2-O4-S

Molecular Weight

  • 1189.3526
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Polymyxin B sulfate [USP:JAN]

Synonyms

  • Aerosporin
  • EINECS 215-774-7
  • Poly-RX
  • Polymixin B sulfate
  • polymixin B sulphate
  • Polymxin B sulfate
  • Polymyxin B sulfate
  • UNII-19371312D4

Systematic Name

  • Polymyxin B, sulfate

Mixture Names

  • Campho-Phenique Antibiotic Plus Pain Relief Ointment
  • Chloromyxin
  • Cortisporin
  • Dexacidin
  • Drotic
  • Maxitrol
  • Neo-Polycin
  • Neobacimyx (Veterinary)
  • Neobacimyx-H (Veterinary)
  • Neosporin
  • Neosporin Plus
  • Ophthocort
  • Otobiotic
  • Otocort
  • Pediotic Suspension
  • Poly-Pred
  • Polysporin
  • Polytrim
  • Statrol
  • Terramycin Ophthalmic

Registry Numbers

CAS Registry Number

  • 1405-20-5

FDA UNII

  • 19371312D4

System Generated Number

  • 0001405205

Molecular Formulas

Molecular Formula

  • C43-H82-N16-O12.x-H2-O4-S

Molecular Formula Fragments

  • C43-H82-N16-O12
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChIKey

HNDFYNOVSOOGDU-UHFFFAOYSA-N

Smiles

CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCC(C(=O)NC(C(=O)NC(C(=O)N1)Cc2ccccc2)CCN)NC(=O)C(CCN)NC(=O)C(CCO)NC(=O)C(CCN)NC=O)CCO)CCN)CCN.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intracrebral 320ug/kg (0.32mg/kg) BEHAVIORAL: COMA British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 552, 1964.
dog LDLo intravenous 8mg/kg (8mg/kg)   Investigative Urology. Vol. 6, Pg. 505, 1969.
guinea pig LD50 subcutaneous 58mg/kg (58mg/kg)   Chemotherapy Vol. 16, Pg. 105, 1968.
mouse LD50 intraperitoneal 20500ug(base) (20.5mg)   Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.
mouse LD50 intravenous 5400ug(base)/ (5.4mg)   Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.
mouse LD50 oral 790mg(base)/k (790mg/kg)   Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.
mouse LD50 subcutaneous 59500ug(base) (59.5mg)   Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.