Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Capreomycin disulfate
RN: 1405-36-3
InChIKey: TUATYNXRYJTQTQ-RIQUSILOSA-N

Note

  • Cyclic peptide antibiotic similar to VIOMYCIN. It is produced by Streptomyces capreolus.

Classification Codes

  • Anti-Bacterial Agents
  • Antibiotics, Antitubercular
  • Drug / Therapeutic Agent
  • Protein Synthesis Inhibitors

Molecular Weight

  • 1517.5818
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Synonyms

  • Capreomycin disulfate
  • Capreomycin sulfate
  • Ogostal

Systematic Name

  • Capreomycin disulfate

Registry Numbers

CAS Registry Number

  • 1405-36-3

System Generated Number

  • 0001405363

Structure Descriptors

InChI

1S/C25H44N14O8.C25H44N14O7.2H2O4S/c26-4-1-2-11(27)6-17(41)32-8-14-20(43)35-15(9-34-25(30)47)21(44)39-18(13-3-5-31-24(29)38-13)23(46)33-7-12(28)19(42)37-16(10-40)22(45)36-14;1-11-19(41)36-15(9-32-17(40)7-12(27)3-2-5-26)21(43)37-16(10-34-25(30)46)22(44)39-18(14-4-6-31-24(29)38-14)23(45)33-8-13(28)20(42)35-11;2*1-5(2,3)4/h9,11-14,16,18,40H,1-8,10,26-28H2,(H,32,41)(H,33,46)(H,35,43)(H,36,45)(H,37,42)(H,39,44)(H3,29,31,38)(H3,30,34,47);10-15,18H,2-9,26-28H2,1H3,(H,32,40)(H,33,45)(H,35,42)(H,36,41)(H,37,43)(H,39,44)(H3,29,31,38)(H3,30,34,46);2*(H2,1,2,3,4)/b15-9+;16-10+;;/t11-,12-,13+,14-,16-,18-;11-,12-,13-,14+,15-,18-;;/m00../s1

InChIKey

TUATYNXRYJTQTQ-RIQUSILOSA-N

Smiles

C[C@@H]1NC(=O)[C@@H](N)CNC(=O)[C@@H](NC(=O)\C(=C/NC(=O)N)\NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC1=O)[C@H]2CCN=C(N)N2.NCCC[C@H](N)CC(=O)NC[C@@H]3NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC(=O)[C@@H](NC(=O)\C(=C/NC(=O)N)\NC3=O)[C@H]4CCN=C(N)N4.OS(=O)(=O)O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous > 62mg/kg (62mg/kg)   Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
guinea pig LDLo subcutaneous > 550mg/kg (550mg/kg)   Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
mouse LD50 intravenous 250mg/kg (250mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

VASCULAR: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
mouse LD50 subcutaneous 514mg/kg (514mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

VASCULAR: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
mouse LDLo oral > 6gm/kg (6000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

VASCULAR: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
rat LD50 intraperitoneal 157mg/kg (157mg/kg) VASCULAR: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
rat LD50 intravenous 325mg/kg (325mg/kg) VASCULAR: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
rat LD50 subcutaneous 1191mg/kg (1191mg/kg) VASCULAR: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.
rat LDLo oral > 6gm/kg (6000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

VASCULAR: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 135, Pg. 960, 1966.