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Substance Name: Capreomycin sulfate [USAN:USP:JAN]
RN: 1405-37-4
UNII: 9H8D3J7V21
InChIKey: TUATYNXRYJTQTQ-RIQUSILOSA-N

Note

  • Cyclic peptide antibiotic similar to VIOMYCIN. It is produced by Streptomyces capreolus.

Classification Codes

  • Antibacterial (Tuberculostatic)
  • Drug / Therapeutic Agent

Molecular Formula

  • H2-O4-S.Unspecified

Molecular Weight

  • 1517.5818
 

Names and Synonyms

Name of Substance

  • Capreomycin sulfate
  • Capreomycin sulfate [USAN:USP:JAN]

MeSH Heading

  • Capreomycin sulfate

Synonyms

  • 34977
  • Capastat
  • Capastat sulfate
  • Capastat sulphate
  • Capreomycin sulfate
  • Caprocin
  • EINECS 215-776-8
  • Ogostal
  • UNII-9H8D3J7V21

Systematic Names

  • Capreomycin sulfate
  • Capreomycin, sulfate (salt)

Registry Numbers

CAS Registry Number

  • 1405-37-4

FDA UNII

  • 9H8D3J7V21

System Generated Number

  • 0001405374

Molecular Formulas

Molecular Formula

  • H2-O4-S.Unspecified

Molecular Formula Fragments

  • COMPONENT
  • H2-O4-S
  • Unspecified

Structure Descriptors

InChI

1S/C25H44N14O8.C25H44N14O7.2H2O4S/c26-4-1-2-11(27)6-17(41)32-8-14-20(43)35-15(9-34-25(30)47)21(44)39-18(13-3-5-31-24(29)38-13)23(46)33-7-12(28)19(42)37-16(10-40)22(45)36-14;1-11-19(41)36-15(9-32-17(40)7-12(27)3-2-5-26)21(43)37-16(10-34-25(30)46)22(44)39-18(14-4-6-31-24(29)38-14)23(45)33-8-13(28)20(42)35-11;2*1-5(2,3)4/h9,11-14,16,18,40H,1-8,10,26-28H2,(H,32,41)(H,33,46)(H,35,43)(H,36,45)(H,37,42)(H,39,44)(H3,29,31,38)(H3,30,34,47);10-15,18H,2-9,26-28H2,1H3,(H,32,40)(H,33,45)(H,35,42)(H,36,41)(H,37,43)(H,39,44)(H3,29,31,38)(H3,30,34,46);2*(H2,1,2,3,4)/b15-9+;16-10+;;/t11-,12-,13+,14-,16-,18-;11-,12-,13-,14+,15-,18-;;/m00../s1

InChIKey

TUATYNXRYJTQTQ-RIQUSILOSA-N

Smiles

C[C@@H]1NC(=O)[C@@H](N)CNC(=O)[C@@H](NC(=O)\C(=C/NC(=O)N)\NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC1=O)[C@H]2CCN=C(N)N2.NCCC[C@H](N)CC(=O)NC[C@@H]3NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC(=O)[C@@H](NC(=O)\C(=C/NC(=O)N)\NC3=O)[C@H]4CCN=C(N)N4.OS(=O)(=O)O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 250mg/kg (250mg/kg)   Drugs in Japan Vol. -, Pg. 259, 1990.
mouse LD50 subcutaneous 514mg/kg (514mg/kg)   Drugs in Japan Vol. 6, Pg. 175, 1982.
rat LD50 intravenous 325mg/kg (325mg/kg)   Drugs in Japan Vol. -, Pg. 259, 1990.
rat LD50 subcutaneous 1191mg/kg (1191mg/kg)   Drugs in Japan Vol. -, Pg. 259, 1990.