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Substance Name: Gentamicin sulfate [USAN:USP:JAN]
RN: 1405-41-0
UNII: 8X7386QRLV

Note

  • A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis ( GENETIC TRANSLATION).

Molecular Formula

  • H2-O4-S.x-Unspecified

Molecular Weight

  • 551.725
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Gentamicin C complex sulfate
  • Gentamicin sulfate [USAN:USP:JAN]
  • Sulmycin-implant

MeSH Heading

  • Gentamicins

Synonyms

  • (Chemical name for gentamicin C(sub 1A).) O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1->4))-2-deoxy-D-streptamine
  • (Chemical name for gentamicin C1A.) O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1-4))-2-deoxy-D-streptamine
  • Apogen
  • Bristagen
  • EINECS 215-778-9
  • Garacin (Veterinary)
  • Garamycin
  • Garasol (Veterinary)
  • Genoptic
  • Genoptic Liquifilm
  • Genoptic S.O.P.
  • Gentacidin
  • Gentafair
  • Gentak
  • Gentalline
  • Gentamicin
  • Gentamicin sulfate
  • Gentamicin sulfate (salt)
  • Gentamicin sulfate in sodium chloride 0.9% in plastic container
  • Gentamycin sulfate
  • GM sulfate
  • Isotonic gentamicin sulfate in plastic container
  • NSC-82261
  • Refobacin
  • Sch 9724
  • U-Gencin
  • UNII-8X7386QRLV

Systematic Names

  • Gentamicin, sulfate
  • Gentamicin, sulfate (salt)

Mixture Names

  • Gentocin (Veterinary)
  • Otomax (Veterinary)
  • Pred-G Liquifilm
  • Pred-G S.O.P.
  • Topagen (Veterinary)

Registry Numbers

CAS Registry Number

  • 1405-41-0

FDA UNII

  • 8X7386QRLV

System Generated Number

  • 0001405410

Molecular Formulas

Molecular Formula

  • H2-O4-S.x-Unspecified

Molecular Formula Fragments

  • COMPONENT
  • H2-O4-S
  • Unspecified

Structure Descriptors

Smiles

O([C@@H]1[C@@H]([C@@H](O[C@@H]2[C@@H](CC[C@@H](O2)*)N)[C@@H](C[C@@H]1N)N)O)[C@@H]1[C@@H]([C@@H]([C@@](C)(O)CO1)NC)O.N([C@@H](C)*)C.C[C@@H](N)*.C(N)*

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 600mg/kg (600mg/kg)   Chemotherapy Vol. 16, Pg. 105, 1968.
man TDLo intravenous 21mg/kg/6D-I (21mg/kg)   Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.
mouse LD50 intracrebral 17300ug/kg (17.3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
Chemotherapy Vol. 15, Pg. 483, 1967.
mouse LD50 intramuscular 250mg/kg (250mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse LD50 intraperitoneal 245mg/kg (245mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
mouse LD50 intravenous 47mg/kg (47mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse LD50 oral > 11269mg/kg (11269mg/kg)   Drugs in Japan Vol. 6, Pg. 268, 1982.
mouse LD50 subcutaneous 478mg/kg (478mg/kg)   Journal of Antibiotics. Vol. 23, Pg. 551, 1970.
rat LD50 intramuscular 384mg/kg (384mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intraperitoneal 630mg/kg (630mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Japanese Journal of Antibiotics. Vol. 26, Pg. 221, 1973.
rat LD50 intravenous 96mg/kg (96mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 8, Pg. 219, 1982.
rat LD50 subcutaneous 873mg(base)/k (873mg/kg)   Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(9), Pg. 26, 1990.
women TDLo intravenous 45mg/kg/1W-I (45mg/kg)   Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 596, 1984.