|
|
Substance Name: Bacitracin [USP:INN:BAN:JAN]
RN: 1405-87-4
UNII: 58H6RWO52I
InChIKey: CLKOFPXJLQSYAH-ABRJDSQDSA-N
Notes
- A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140).
- TSCA Definition 2021: A complex combination of polypeptides produced by the metabolic processes of Bacillus subtilis and licheniformis.
Molecular Formula
- Unspecified
Molecular Weight
- 1422.7087
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antibacterial
- Drug / Therapeutic Agent
- Mutation Data
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Bacitracin
- Bacitracin [USP:INN:BAN:JAN]
MeSH Heading
- Bacitracin
Synonyms
- AI3-50147-X
- Ak-Tracin
- Altracin
- Ayfivin
- Baci-Jel
- Baci-RX
- Baciguent
- Baciim
- Baciliquin
- Bacitek ointment
- Bacitracin
- Bacitracin-Neomycin-Polymyxin Ointment
- Bacitracina
- Bacitracina [Spanish]
- Bacitracine
- Bacitracine [French]
- Bacitracinum
- Bacitracinum [Latin]
- Bactine Triple Antibiotic
- Campho-Phenique Triple Plus Pain Reliever
- EINECS 215-786-2
- Fortracin
- HSDB 6418
- Mycitracin Plus Pain Reliever
- Mycitracin Triple Antibiotic First Aid Ointment Maximum Strength
- NSC 755905
- Parentracin
- Penitracin
- Septa
- Spectrocin Plus
- Topitracin
- Topitrasin
- UNII-58H6RWO52I
- USAF CB-7
- Zutracin
Systematic Name
- Bacitracin
Superlist Name
- Bacitracin
Mixture Name
- Mycitracin
Registry Numbers
CAS Registry Number
- 1405-87-4
FDA UNII
- 58H6RWO52I
Other Registry Numbers
- 12640-37-8
- 1405-75-0
- 60454-67-3
Related Registry Number
- 1405-89-6 (zinc complex)
System Generated Number
- 0001405874
Structure Descriptors
InChI
InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54-/m0/s1InChIKey
CLKOFPXJLQSYAH-ABRJDSQDSA-NSmiles
CC[C@H](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 2gm/kg (2000mg/kg) | Antibiotics and Chemotherapy Vol. 4, Pg. 304, 1954. | |
mouse | LD50 | intraperitoneal | 300mg/kg (300mg/kg) | National Technical Information Service. Vol. AD277-689, | |
mouse | LD50 | intravenous | 360mg/kg (360mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Proceedings of the Society for Experimental Biology and Medicine. Vol. 64, Pg. 503, 1947. |
mouse | LD50 | oral | > 3750mg/kg (3750mg/kg) | Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960. | |
mouse | LD50 | subcutaneous | 1300mg/kg (1300mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 64, Pg. 503, 1947. |
quail | LD50 | oral | > 316mg/kg (316mg/kg) | Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. | |
rat | LD50 | intraperitoneal | 190mg/kg (190mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Proceedings of the Society for Experimental Biology and Medicine. Vol. 64, Pg. 503, 1947. |