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Substance Name: Penicillins
RN: 1406-05-9

Note

  • A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)

Molecular Weight

  • 257.289
 

Classification Codes

  • Anti-Bacterial Agents
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Results Name

  • Penicillins

MeSH Heading

  • Penicillins

Synonyms

  • EINECS 215-794-6
  • Penizillin [German]

Systematic Name

  • Penicillin

Registry Numbers

CAS Registry Number

  • 1406-05-9

Other Registry Numbers

  • 88326-90-3
  • 88326-91-4
  • 88326-92-5
  • 88326-93-6

System Generated Number

  • 0001406059

Structure Descriptors

Smiles

*CC(N[C@@H]1C(N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 30mg/kg (30mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1663, 1978.
guinea pig LD50 subcutaneous 30mg/kg (30mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 1663, 1978.
man TDLo intramuscular 12385ug/kg/16 (12.385mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Medical Journal of Australia. Vol. 1, Pg. 305, 1947.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 1, 1955.
mouse LDLo intravenous 1gm/kg (1000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 70, 1943.
mouse LDLo subcutaneous 3200mg/kg (3200mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 70, 1943.