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Substance Name: Polymyxin
RN: 1406-11-7
InChIKey: WGRSQPZAOZIPGC-VVYZPAMCSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Weight

  • 1107.2738
 
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Names and Synonyms

Name of Substance

  • Polymyxin

Synonyms

  • B-71
  • Caswell No. 678
  • EPA Pesticide Chemical Code 006305
  • Polymyxin
  • Polymyxinum

Systematic Name

  • Polymyxin

Registry Numbers

CAS Registry Number

  • 1406-11-7

System Generated Number

  • 0001406117

Structure Descriptors

InChI

1S/C48H82N16O14/c1-24(2)22-34-44(73)57-28(10-16-49)38(67)56-31(13-19-52)42(71)63-36(25(3)65)46(75)54-21-15-33(41(70)55-29(11-17-50)40(69)61-35(45(74)60-34)23-27-8-6-5-7-9-27)58-39(68)30(12-18-51)59-47(76)37(26(4)66)64-43(72)32(14-20-53)62-48(77)78/h5-9,24-26,28-37,62,65-66H,10-23,49-53H2,1-4H3,(H,54,75)(H,55,70)(H,56,67)(H,57,73)(H,58,68)(H,59,76)(H,60,74)(H,61,69)(H,63,71)(H,64,72)(H,77,78)/t25-,26-,28+,29+,30+,31+,32+,33+,34+,35-,36+,37+/m1/s1

InChIKey

WGRSQPZAOZIPGC-VVYZPAMCSA-N

Smiles

C[C@H]([C@H]1C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCN)CCN)CC(C)C)Cc2ccccc2)CCN)NC(=O)[C@H](CCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 25mg/kg (25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949.
mouse LD50 intraperitoneal 77mg/kg (77mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Annals of the New York Academy of Sciences. Vol. 51, Pg. 879, 1949.
mouse LD50 subcutaneous 250mg/kg (250mg/kg) BEHAVIORAL: ATAXIA

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Annals of the New York Academy of Sciences. Vol. 51, Pg. 935, 1949.