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Substance Name: MITF protein, Aspergillus restrictus
RN: 1406-72-0

Note

  • A phosphodiesterase making it a Ribonuclease distinguishing it from ribosome inactivating protein that deadenylate; a ribotoxin from Aspergillus; MW 16 kDa; sequence 85% identity to alpha-sarcin.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Synthesis Inhibitors
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Links to Resources

Names and Synonyms

Name of Substance

  • MITF protein, Aspergillus restrictus

Synonyms

  • A 8671K119
  • Mitogillin
  • NSC 53398
  • NSC-53398
  • Restrictocin protein, Aspergillus restrictus
  • Ribonuclease mitogillin

Systematic Names

  • Amino acid sequence:ATWTCINQQL NPKTNKWEDK RLLYSQAKAE SNSHHAPLSD GKTGSSYPHW FTNGYDGNGK LIKGRTPIKF GKADCDRPPK HSQNGMGKDD HYLLEFPTFP DGHDYKFDSK KPKENPGPAR VIYTYPNKVF CGIVAHQRGN QGDLRLCSH
  • Restrictocin

Registry Numbers

CAS Registry Number

  • 1406-72-0

System Generated Number

  • 0001406720

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 20mg/kg (20mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
National Cancer Institute Report. Vol. -, Pg. 9, 1964.
mouse LD50 oral > 400mg/kg (400mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: HEMORRHAGE
National Cancer Institute Report. Vol. -, Pg. 9, 1964.
rat LD50 intravenous 30mg/kg (30mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
National Cancer Institute Report. Vol. -, Pg. 9, 1964.