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Substance Name: Leukocidin
RN: 1406-83-3

Note

  • Pore forming proteins originally discovered for toxic activity to LEUKOCYTES. They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Cytotoxins
  • Drug / Therapeutic Agent
  • Natural Product
  • Noxae
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Links to Resources

Names and Synonyms

MeSH Heading

  • Leukocidins

Synonyms

  • Leucocidin
  • Leukocidin (Staphylococcus aureus & Pseudomonas aeruginos)
  • Pseudomonas aeruginos cytotoxin
  • Staphylococcus aureus cytotoxin

Systematic Name

  • Leukocidin

Registry Numbers

CAS Registry Number

  • 1406-83-3

System Generated Number

  • 0001406833

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 250ug/kg (0.25mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 11(1), Pg. 608, 1985.
mouse LD50 intravenous 7950ug/kg (7.95mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 381, 1967.