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Substance Name: Muromonab-CD3 [USAN:INN:JAN]
RN: 140608-64-6
UNII: JGA39ICE2V

Note

  • Anti-CD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral T-cell depletion and modulation of the T-cell receptor complex (CD3/Ti).

Molecular Formula

  • Unspecified
 

Classification Codes

  • Immunologic Factors
  • Immunosuppressive Agents
  • Monoclonal Antibody (Immunosuppressant)

Names and Synonyms

Name of Substance

  • Muromonab-CD3
  • Muromonab-CD3 [USAN:INN:JAN]

MeSH Heading

  • Muromonab-CD3

Synonyms

  • Muromonab-CD3
  • OKT 3
  • OKT3
  • Orthoclone OKT3
  • UNII-JGA39ICE2V

Systematic Name

  • Muromonab CD3

Registry Numbers

CAS Registry Number

  • 140608-64-6

FDA UNII

  • JGA39ICE2V

System Generated Number

  • 0140608646

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo parenteral 128ug/kg/3D-I (0.128mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: OTHER CHANGES
American Journal of Kidney Diseases. Vol. 17, Pg. 73, 1991.
mouse LD50 intravenous > 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
mouse LD50 oral > 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
mouse LD50 subcutaneous > 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
rat LD50 intravenous > 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
rat LD50 oral > 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.
rat LD50 subcutaneous > 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991.