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Substance Name: Felbinac ethyl [JAN]
RN: 14062-23-8
UNII: 978ZPS989U
InChIKey: NPPJLSILDPVHCM-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C16-H16-O2

Molecular Weight

  • 240.3
 
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Names and Synonyms

Name of Substance

  • 4-Biphenylylacetic acid ethyl ester
  • Felbinac ethyl ester
  • Felbinac ethyl [JAN]

Synonyms

  • (1,1'-Biphenyl)-4-acetic acid ethyl ester
  • 3-09-00-03321 (Beilstein Handbook Reference)
  • Acetic acid, (4-biphenylyl)-, ethyl ester
  • BRN 2052035
  • Ethyl (4-biphenylyl)acetate
  • Ethyl p-biphenylylacetate
  • Felbinac ethyl
  • LM-001
  • UNII-978ZPS989U

Systematic Name

  • 4-Biphenylacetic acid, ethyl ester

Registry Numbers

CAS Registry Number

  • 14062-23-8

FDA UNII

  • 978ZPS989U

System Generated Number

  • 0014062238

Structure Descriptors

InChI

1S/C16H16O2/c1-2-18-16(17)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,2,12H2,1H3

InChIKey

NPPJLSILDPVHCM-UHFFFAOYSA-N

Smiles

c1(c2ccccc2)ccc(CC(OCC)=O)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: NAUSEA OR VOMITING
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3437, 1987.
mouse LD50 intravenous 337mg/kg (337mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3437, 1987.
mouse LD50 oral 652mg/kg (652mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3437, 1987.
mouse LD50 subcutaneous 646mg/kg (646mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3437, 1987.
rat LD50 intravenous 288mg/kg (288mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3437, 1987.
rat LD50 oral 385mg/kg (385mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3437, 1987.
rat LD50 subcutaneous 321mg/kg (321mg/kg) GASTROINTESTINAL: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3437, 1987.