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Substance Name: Mangafodipir trisodium [USAN:USP]
RN: 140678-14-4
UNII: 129FW80TG4
InChIKey: BENFPBJLMUIGGD-UHFFFAOYSA-I

Classification Codes

  • Diagnostic (Paramagnetic Contrast Agent)
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C22-H24-Mn-N4-O14-P2.3H.3Na

Molecular Weight

  • 759.3411
 
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Names and Synonyms

Name of Substance

  • Mangafodipir trisodium [USAN:USP]

Synonyms

  • Mangafodipir trisodium
  • Teslascan
  • Trisodium trihydrogen (OC-6-13)-((N,N'-1,2-ethanediylbis(N-((3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinyl)methyl)glycinato))(8-)manganate(6-)
  • Trisodium trihydrogen (OC-6-13)-((N,N'-ethylenebis(N-((3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridyl)methyl)glycine) 5,5'-bis(phosphato))(8-))manganate(6-)
  • UNII-129FW80TG4
  • Win 59010

Systematic Name

  • Manganate(6-), ((N,N'-1,2-ethanediylbis(N-((3-hydroxy-2-methyl-5-((phosphonooxy)-methyl)-4-pyridinyl)methyl)glycinato)) (8-))-, trisodium trihydrogen, (OC-6-13)-

Registry Numbers

CAS Registry Number

  • 140678-14-4

FDA UNII

  • 129FW80TG4

System Generated Number

  • 0140678144

Molecular Formulas

Molecular Formula

  • C22-H24-Mn-N4-O14-P2.3H.3Na

Molecular Formula Fragments

  • C22-H24-Mn-N4-O14-P2
  • COMPONENT
  • H
  • Na

Structure Descriptors

InChI

1S/C22H32N4O14P2.Mn.3Na/c1-13-21(31)17(15(5-23-13)11-39-41(33,34)35)7-25(9-19(27)28)3-4-26(10-20(29)30)8-18-16(12-40-42(36,37)38)6-24-14(2)22(18)32;;;;/h5-6,31-32H,3-4,7-12H2,1-2H3,(H,27,28)(H,29,30)(H2,33,34,35)(H2,36,37,38);;;;/q;+2;3*+1/p-5

InChIKey

BENFPBJLMUIGGD-UHFFFAOYSA-I

Smiles

n1c(C)c([O-])c(c(COP(=O)([O-])[O-])c1)C[N@@](CC[N@@](Cc1c(cnc(c1[O-])C)COP(=O)([O-])[O-])CC([O-])=O)CC([O-])=O.[Mn+2].[Na+].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 1666mg/kg (1666mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Acta Radiologica. Vol. 38, Pg. 770, 1997.
mouse LD50 intravenous 1439mg/kg (1439mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Acta Radiologica. Vol. 38, Pg. 770, 1997.
mouse LD50 unreported 2954mg/kg (2954mg/kg)   Acta Radiologica, Supplementum. Vol. 394, Pg. 32-52, 1994.
rat LD50 intravenous > 2196mg/kg (2196mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Acta Radiologica. Vol. 38, Pg. 770, 1997.