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Substance Name: Osutidine [INN]
RN: 140695-21-2
UNII: YDB1AQ7N4L
InChIKey: GZPOYVTZKHVRHE-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H28-N4-O5-S2

Molecular Weight

  • 456.585
 
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Names and Synonyms

Results Name

  • Osutidine [INN]

Name of Substance

  • Osutidine [INN]
  • T 593

Synonyms

  • (+-)-N-((E)-((p,beta-Dihydroxyphenethyl)amino)((2-((5-((methylamino)methyl)furfuryl)thio)ethyl)amino)methylene)methanesulfonamide
  • CCRIS 8408
  • Osutidine
  • T 593
  • T-593
  • T593
  • UNII-YDB1AQ7N4L

Systematic Names

  • GenBank M36922
  • Methanesulfonamide, N-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)amino)((2-(((5-((methylamino)methyl)-2-furanyl)methyl)thio)ethyl)amino)methylene)-, (E)-

Registry Numbers

CAS Registry Number

  • 140695-21-2

FDA UNII

  • YDB1AQ7N4L

System Generated Number

  • 0140695212

Structure Descriptors

InChI

1S/C19H28N4O5S2/c1-20-11-16-7-8-17(28-16)13-29-10-9-21-19(23-30(2,26)27)22-12-18(25)14-3-5-15(24)6-4-14/h3-8,18,20,24-25H,9-13H2,1-2H3,(H2,21,22,23)

InChIKey

GZPOYVTZKHVRHE-UHFFFAOYSA-N

Smiles

CS(=O)(=O)\N=C(\NCCSCc1oc(cc1)CNC)NC[C@@H](c1ccc(cc1)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Oyo Yakuri. Pharmacometrics. Vol. 55, Pg. 139, 1998.
dog LDLo intravenous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Oyo Yakuri. Pharmacometrics. Vol. 55, Pg. 139, 1998.
rat LD50 intravenous 83900ug/kg (83.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 55, Pg. 139, 1998.
rat LD50 oral > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 55, Pg. 139, 1998.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 55, Pg. 139, 1998.